Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

C-reactive protein – more than a heart disease marker

27.01.2004


C-reactive protein, already accepted as indicating a risk of heart disease, also participates in the process of atherosclerosis that narrows heart arteries, said a Baylor College of Medicine (BCM) researcher.



In a report that went online in the "rapid track" portion of the website of Circulation, the journal of the American Heart Association, today, Dr. Lawrence Chan, chief of the BCM division of diabetes, endocrinology and metabolism, and members of his laboratory said that when mice genetically prone to develop atherosclerosis also produced a human form of C-reactive protein, they developed larger lesions associated with the buildup of fatty plaque in the arteries than did those who did not produce the protein.

"Our study supports the use of C-reactive protein as a marker of risk for heart disease," said Chan. "Not only that, but it identifies at least one mechanism by which the protein contributes to the development of atherosclerosis." He said this is the first time these facts have been demonstrated in living animals.


Atherosclerosis is associated with deposits of fatty plaque in the walls of arteries. When this significantly narrows the heart’s arteries, patients face an increased risk of heart attack.

C-reactive protein is an indication that there is inflammation in the body. When its levels are high, physicians suspect that an individual’s risk of developing heart disease is equally elevated. Chan and his colleagues, including Dr. Antoni Paul, a postdoctoral fellow at BCM who did most of the laboratory analysis, identified high levels of an arterial wall cell surface protein called angiotensin type 1 receptor in the atherosclerotic deposits in the mice that expressed C-reactive protein. Mice that lacked C-reactive protein had lower levels of the receptor.

High levels of the receptor make cells more susceptible to inflammatory attack, said Chan. Some medications now used to treat heart disease block a form of angiotensin receptor and could be more effective in individuals with high levels of C-reactive protein, he said.

Further research will be needed to confirm that, he said.

Anissa Orr | EurekAlert!
Further information:
http://research.bcm.tmc.edu/

More articles from Health and Medicine:

nachricht World first: Massive thrombosis removed during early pregnancy
20.07.2017 | Universitätsspital Bern

nachricht Therapy of preterm birth in sight?
19.07.2017 | Universitätsspital Bern

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA looks to solar eclipse to help understand Earth's energy system

21.07.2017 | Earth Sciences

Stanford researchers develop a new type of soft, growing robot

21.07.2017 | Power and Electrical Engineering

Vortex photons from electrons in circular motion

21.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>