Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

C-reactive protein – more than a heart disease marker

27.01.2004


C-reactive protein, already accepted as indicating a risk of heart disease, also participates in the process of atherosclerosis that narrows heart arteries, said a Baylor College of Medicine (BCM) researcher.



In a report that went online in the "rapid track" portion of the website of Circulation, the journal of the American Heart Association, today, Dr. Lawrence Chan, chief of the BCM division of diabetes, endocrinology and metabolism, and members of his laboratory said that when mice genetically prone to develop atherosclerosis also produced a human form of C-reactive protein, they developed larger lesions associated with the buildup of fatty plaque in the arteries than did those who did not produce the protein.

"Our study supports the use of C-reactive protein as a marker of risk for heart disease," said Chan. "Not only that, but it identifies at least one mechanism by which the protein contributes to the development of atherosclerosis." He said this is the first time these facts have been demonstrated in living animals.


Atherosclerosis is associated with deposits of fatty plaque in the walls of arteries. When this significantly narrows the heart’s arteries, patients face an increased risk of heart attack.

C-reactive protein is an indication that there is inflammation in the body. When its levels are high, physicians suspect that an individual’s risk of developing heart disease is equally elevated. Chan and his colleagues, including Dr. Antoni Paul, a postdoctoral fellow at BCM who did most of the laboratory analysis, identified high levels of an arterial wall cell surface protein called angiotensin type 1 receptor in the atherosclerotic deposits in the mice that expressed C-reactive protein. Mice that lacked C-reactive protein had lower levels of the receptor.

High levels of the receptor make cells more susceptible to inflammatory attack, said Chan. Some medications now used to treat heart disease block a form of angiotensin receptor and could be more effective in individuals with high levels of C-reactive protein, he said.

Further research will be needed to confirm that, he said.

Anissa Orr | EurekAlert!
Further information:
http://research.bcm.tmc.edu/

More articles from Health and Medicine:

nachricht NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)

nachricht High speed video recording precisely measures blood cell velocity
15.11.2017 | ITMO University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>