The eradication of leprosy, one of the world’s oldest and most feared diseases, may be one step closer. An international research team lead by scientists from the Research Institute of the McGill University Health Centre (MUHC) discovered that small changes in certain genes, the Parkin 2 gene and its neighbor, PACRG, result in an increased susceptibility to leprosy. Parkin 2 has also been shown to cause certain forms of Parkinson’s Disease, a common neuro-degenerative disease in developed countries. These findings will be published in the February issue of the research journal Nature. The research was supported by the Canadian Genetic Diseases Network (CGDN), Canadian Institutes of Health Research (CIHR), and granting institutions in France and the Netherlands.
"Our results give an entirely novel view of the leprosy disease process," says MUHC molecular geneticist and James McGill Professor Dr. Erwin Schurr, one of the lead authors of the study that included scientists and physicians from Vietnam, Brazil, The Netherlands, France and Canada. "Our findings may hold the key to unravel why, despite effective drug treatment, leprosy persists in many parts of the world."
"Leprosy has plagued humans for many centuries and it continues to be a concern in many countries," says co-investigator Dr. Laurent Abel, study co-author and Research Director at Institut National de la Santé et de la Recherche Médical (INSERM) Unité 550 at Necker Medical School, Université René Descartes.
Christine Zeindler | McGill University
Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
28.04.2017 | Event News
20.04.2017 | Event News
18.04.2017 | Event News
28.04.2017 | Medical Engineering
28.04.2017 | Earth Sciences
28.04.2017 | Life Sciences