Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Drug prevents diabetes recurrence after islet cell transplantation

20.01.2004


A new anti-inflammatory compound called Lisofylline prevents diabetes from coming back after insulin-manufacturing islet cells are transplanted into diabetic mice, according to a new study by researchers at the University of Virginia Health System. The study is published in the January 20 issue of the journal Transplantation.



Pancreatic islet cell transplantation has become a promising treatment for type 1 diabetes in humans in recent years. But without several powerful immunosuppressive drugs, the body’s immune system would destroy the engrafted islet cells in transplant patients leading to insulin deficiency, an excess of glucose in the blood and the return of diabetes.

Lisofylline, or LSF, has the potential to help prevent this cellular destruction by preserving insulin secretion by pancreatic beta cells in the presence of autoimmune attackers called inflammatory cytokines, according to U.Va. researchers.


"Our findings are very encouraging and we are excited that Lisofylline worked so well in this animal model," said Dr. Jerry Nadler, chief of the division of endocrinology and metabolism at U.Va. and director of the Diabetes and Hormone Center of Excellence. "We have discovered a potentially new way to protect islet cells in a clinical transplant setting. It’s possible this research could form a basis for additional studies to use LSF or related anti-inflammatory compounds in humans to limit the need for more toxic immunosuppressant drugs in islet cell transplant patients."

In the study, diabetic mice that can only mount an autoimmune attack were given islet transplants in the kidney and then daily injections of LSF for 3 weeks. A control group was treated with only saline. Results of blood glucose tests showed that the LSF-treated mice maintained healthy glucose levels, without immunosuppressants and insulin, for more than 65 days. Mice treated with saline maintained healthy glucose levels for just six days. After researchers removed the kidneys, tests showed that insulin-positive beta cells had been retained in the islet cell grafts of the LSF-treated mice.

"We have found that Lisofylline has a unique function in protecting insulin-producing beta cells," said Dr. Zandong Yang, study co-author and assistant professor of research in the division of endocrinology and metabolism at U.Va. "At the cellular level, LSF inhibits a pathway that delivers cytokine damage to beta cells. At the molecular level, we believe LSF enhances the life-span and energy production of beta cells by increasing metabolism in the cellular mitochondria, the engine of a cell."

Yang says U.Va. researchers are hoping to test LSF in human islet cell transplant patients as part of the solution that surrounds the isolated islets. "This would be a great help and protect these cells from dying," he said.


The study was funded in part by grants from the Juvenile Diabetes Research Foundation and the Islet Replacement Research Foundation in Gordonsville, Va.

Bob Beard | EurekAlert!
Further information:
http://hsc.virginia.edu/news

More articles from Health and Medicine:

nachricht Hot cars can hit deadly temperatures in as little as one hour
24.05.2018 | Arizona State University

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

Beyond the limits of conventional electronics: stable organic molecular nanowires

24.05.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>