Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Drug prevents diabetes recurrence after islet cell transplantation

20.01.2004


A new anti-inflammatory compound called Lisofylline prevents diabetes from coming back after insulin-manufacturing islet cells are transplanted into diabetic mice, according to a new study by researchers at the University of Virginia Health System. The study is published in the January 20 issue of the journal Transplantation.



Pancreatic islet cell transplantation has become a promising treatment for type 1 diabetes in humans in recent years. But without several powerful immunosuppressive drugs, the body’s immune system would destroy the engrafted islet cells in transplant patients leading to insulin deficiency, an excess of glucose in the blood and the return of diabetes.

Lisofylline, or LSF, has the potential to help prevent this cellular destruction by preserving insulin secretion by pancreatic beta cells in the presence of autoimmune attackers called inflammatory cytokines, according to U.Va. researchers.


"Our findings are very encouraging and we are excited that Lisofylline worked so well in this animal model," said Dr. Jerry Nadler, chief of the division of endocrinology and metabolism at U.Va. and director of the Diabetes and Hormone Center of Excellence. "We have discovered a potentially new way to protect islet cells in a clinical transplant setting. It’s possible this research could form a basis for additional studies to use LSF or related anti-inflammatory compounds in humans to limit the need for more toxic immunosuppressant drugs in islet cell transplant patients."

In the study, diabetic mice that can only mount an autoimmune attack were given islet transplants in the kidney and then daily injections of LSF for 3 weeks. A control group was treated with only saline. Results of blood glucose tests showed that the LSF-treated mice maintained healthy glucose levels, without immunosuppressants and insulin, for more than 65 days. Mice treated with saline maintained healthy glucose levels for just six days. After researchers removed the kidneys, tests showed that insulin-positive beta cells had been retained in the islet cell grafts of the LSF-treated mice.

"We have found that Lisofylline has a unique function in protecting insulin-producing beta cells," said Dr. Zandong Yang, study co-author and assistant professor of research in the division of endocrinology and metabolism at U.Va. "At the cellular level, LSF inhibits a pathway that delivers cytokine damage to beta cells. At the molecular level, we believe LSF enhances the life-span and energy production of beta cells by increasing metabolism in the cellular mitochondria, the engine of a cell."

Yang says U.Va. researchers are hoping to test LSF in human islet cell transplant patients as part of the solution that surrounds the isolated islets. "This would be a great help and protect these cells from dying," he said.


The study was funded in part by grants from the Juvenile Diabetes Research Foundation and the Islet Replacement Research Foundation in Gordonsville, Va.

Bob Beard | EurekAlert!
Further information:
http://hsc.virginia.edu/news

More articles from Health and Medicine:

nachricht Antibiotic effective against drug-resistant bacteria in pediatric skin infections
17.02.2017 | University of California - San Diego

nachricht Tiny magnetic implant offers new drug delivery method
14.02.2017 | University of British Columbia

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Biocompatible 3-D tracking system has potential to improve robot-assisted surgery

17.02.2017 | Medical Engineering

Real-time MRI analysis powered by supercomputers

17.02.2017 | Medical Engineering

Antibiotic effective against drug-resistant bacteria in pediatric skin infections

17.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>