In one of the biggest advances to come from the H. Lee Moffitt Cancer Center & Research Institute in its 16-year history, researchers have unlocked at least part of the mystery of how tumors flourish undetected by keeping their presence a secret from sentries of the bodys immune system.
"Flying beneath the radar" is how Nature Reviews Cancer (http://www.nature.com/cgi-taf/DynaPage.taf?file=/nrc/journal/v4/n1/full/nrc1261_fs.html) labels the mechanism of tumors evading capture, a process described by Hua Yu, Ph.D., and her colleagues at Moffitt and the University of South Florida College of Medicine. Their findings are published in the current issue of the journal Nature Medicine.
"Cancer is allowed to wreak havoc on the bodys immune system because it knows how to fool the bodys defensive arsenal," explains Jack Pledger, Ph.D., Associate Center Director for Basic Science and Professor of Biochemistry at USF. "The discoveries of Dr. Yu give us vital information about how tumors stay invisible. It opens the way for new treatments to help flush the cancer cells into the open, so the bodys armies against disease can destroy them."
Andrea Brunais | EurekAlert!
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