Milestone discovery of the 3-D structure and function of vinculin explains how this protein changes its shape to perform different functions in health and disease
The discovery of how a protein called vinculin undergoes exquisitely precise changes in its shape is helping to answer some major questions about the life of cells, the development of tissues and organs and the spread of cancer from one part of the body to another. These findings, to be published in the Jan. 8, 2004, issue of Nature, were made by scientists at St. Jude Childrens Research Hospital.
The newly recognized way that this protein can change its shape is important because slight changes in the shape of vinculin completely change its role in the cell, making the protein a versatile tool for completing different tasks. For example, by alternately changing its shape from active to inactive forms, vinculin can control the cells ability to remain stationary or move through its environment.
Bonnie Cameron | EurekAlert!
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A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
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The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
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The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
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