Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

University of Pittsburgh studies broccoli-derived chemicals to prevent prostate cancer

23.12.2003


Fruits and vegetables are good for overall health, and a newly funded study at the University of Pittsburgh Cancer Institute (UPCI) may show that certain vegetables, such as broccoli, also offer protection against prostate cancer.



UPCI researcher Shivendra Singh, Ph.D., professor of pharmacology and urology at the University of Pittsburgh School of Medicine, has received a $1.7 million grant from the National Cancer Institute to study prostate cancer prevention by phytochemicals found in broccoli called isothiocyanates (ITCs).

"Clearly, what we eat has an effect on the development of diseases such as cancer," said Dr. Singh, also co-leader of UPCI’s cancer biochemoprevention program. "However, we know little about the mechanisms by which certain edible plants like broccoli help our bodies fight prostate cancer and other diseases. Our goal with this study is to better understand the function and relationship of substances in broccoli that appear to be linked to inhibiting prostate cancer growth."


ITCs are substances in vegetables that are generated when vegetables are either cut or chewed. Previous research has demonstrated that ITCs are highly effective in affording protection against cancer in animal models induced by carcinogens including those in tobacco smoke. Epidemiological research also has shown that increased consumption of vegetables that contain ITCs significantly reduces the risk for prostate cancer.

Dr. Singh’s laboratory has found that some naturally occurring ITCs are highly effective in suppressing the growth of human prostate cancer cells at concentrations that are achievable through dietary intake of cruciferous vegetables such as watercress and broccoli. In his current study, Dr. Singh seeks to further define the mechanisms by which ITCs induce apoptosis, or cancer cell death, to provide insights into the key structural relationships between ITCs and cell processes and to identify potential biomarkers that could be useful for future intervention trials involving ITCs.

"The knowledge we gain from this study will help guide us in formulating practical and effective nutritional strategies for the prevention and treatment of prostate cancer," said Dr. Singh. In addition to studies involving broccoli, Dr. Singh also is examining the effect of garlic on prostate cancer prevention.

In the United States, only 23 percent of adults eat five or more fruits and vegetables per day.


Clare Collins
Jocelyn Uhl
PHONE: 412-647-3555
FAX: 412-624-3184
E-MAIL:
CollCX@upmc.edu
UhlJH@upmc.edu

Brenda Hudson | EurekAlert!
Further information:
http://www.upmc.edu/

More articles from Health and Medicine:

nachricht Nanoparticles as a Solution against Antibiotic Resistance?
15.12.2017 | Friedrich-Schiller-Universität Jena

nachricht Plasmonic biosensors enable development of new easy-to-use health tests
14.12.2017 | Aalto University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>