Scientists at Washington University School of Medicine in St. Louis have found that the absence of two proteins cells use to cope with heat stress can make it easier for the cells to become cancerous, but that same absence also makes it harder for cancerous cells to survive exposure to heat and radiation.
The findings mark the two proteins, Heat shock protein (Hsp) 70.1 and 70.3, as potential targets for gene therapy that could increase cancer cells vulnerability to treatments.
"This is the first time weve linked these proteins to the cancer cells response to ionizing radiation," says Tej Pandita, Ph.D., assistant professor of radiation oncology and lead investigator of the new study. "Understanding the pathobiology of the genes that make these proteins -- how they function in normal circumstances and how they work in an unusual context like the cancer cell -- will help radiation oncologists devise gene therapy protocols that enhance cell kill from radiation treatments."
Michael C. Purdy | WUSTL School of Medicine
'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS
New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
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