Scientists at Washington University School of Medicine in St. Louis have found that the absence of two proteins cells use to cope with heat stress can make it easier for the cells to become cancerous, but that same absence also makes it harder for cancerous cells to survive exposure to heat and radiation.
The findings mark the two proteins, Heat shock protein (Hsp) 70.1 and 70.3, as potential targets for gene therapy that could increase cancer cells vulnerability to treatments.
"This is the first time weve linked these proteins to the cancer cells response to ionizing radiation," says Tej Pandita, Ph.D., assistant professor of radiation oncology and lead investigator of the new study. "Understanding the pathobiology of the genes that make these proteins -- how they function in normal circumstances and how they work in an unusual context like the cancer cell -- will help radiation oncologists devise gene therapy protocols that enhance cell kill from radiation treatments."
Michael C. Purdy | WUSTL School of Medicine
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MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
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