Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tailored dosage of chemotherapy effective in treating breast cancer

16.12.2003


By tailoring the dosage of chemotherapy to each individual patient, the treatment of breast cancer could be improved considerably. This is shown in a dissertation by Uppsala researcher Henrik Lindman at Uppsala University in Sweden. The method has proven to yield excellent results in clinical tests.



The dissertation reports that an alternative way of tailoring the dosage of chemotherapy has been studied and found to work. If the advantages of this method compared to standard treatment can be verified in the follow-up study that has just been completed on more than 1,500 patients in Sweden and Denmark, we may be facing a more extensive change in the treatment of cancer, one that reaches far beyond the sphere of breast cancer. One clear advantage of the method, apart from fewer side-effects and less risk of under-dosage, is that it should provide a way of determining the value of new chemotherapies, since it is probable that tailored dosages will prevent improper dosage regimens to a greater extent than previously.

In treating cancer, the dosage of chemotherapy is normally determined on the basis of the body surface area of the patient, which factors in height and weight. This method has proven to be insufficient when it comes to differences among patients in the amount of chemotherapy in the blood. Some patients receive overdoses with severe side-effects as a result, while others receive under-dosed regimens that risk leaving the tumor insufficiently treated.


Henrik Lindman has studied a method of tailoring just the right dosage for each patient. This is done by measuring the decline in, above all, white corpuscles after each treatment and thereafter adjusting the following treatment. The method proved successful in the three different pioneering trials on women with breast cancer. The differences in tolerated chemotherapy were up to a factor of three across different patients, which, among other things, may be dependent on genetic differences in sensitivity. In a Nordic collaborative project, 525 women with breast cancer at high risk of recurrence were selected for treatment. Half of the patients received 9 doses of tailored treatment while the other half received high-dosage regimens with bone-marrow transplants after three standard dosages of chemotherapy. Patients receiving tailored treatment experienced a lower rate of recurrence of breast cancer (28% compared with 37% after 3 years).

The other two studies involved, respectively, 26 and 44 patients with metastasized breast cancer. Here, too, the effect of treatment was good in comparison with previous experience (81% and 63%, respectively, saw a dramatic reduction in their tumors). Women who could withstand the highest dosages did not experience more general side-effects than those who were given lower dosages.

Anneli Waara | alfa
Further information:
http://www.uu.se

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Osaka university researchers make the slipperiest surfaces adhesive

18.10.2017 | Materials Sciences

Space radiation won't stop NASA's human exploration

18.10.2017 | Physics and Astronomy

Los Alamos researchers and supercomputers help interpret the latest LIGO findings

18.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>