Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tailored dosage of chemotherapy effective in treating breast cancer

16.12.2003


By tailoring the dosage of chemotherapy to each individual patient, the treatment of breast cancer could be improved considerably. This is shown in a dissertation by Uppsala researcher Henrik Lindman at Uppsala University in Sweden. The method has proven to yield excellent results in clinical tests.



The dissertation reports that an alternative way of tailoring the dosage of chemotherapy has been studied and found to work. If the advantages of this method compared to standard treatment can be verified in the follow-up study that has just been completed on more than 1,500 patients in Sweden and Denmark, we may be facing a more extensive change in the treatment of cancer, one that reaches far beyond the sphere of breast cancer. One clear advantage of the method, apart from fewer side-effects and less risk of under-dosage, is that it should provide a way of determining the value of new chemotherapies, since it is probable that tailored dosages will prevent improper dosage regimens to a greater extent than previously.

In treating cancer, the dosage of chemotherapy is normally determined on the basis of the body surface area of the patient, which factors in height and weight. This method has proven to be insufficient when it comes to differences among patients in the amount of chemotherapy in the blood. Some patients receive overdoses with severe side-effects as a result, while others receive under-dosed regimens that risk leaving the tumor insufficiently treated.


Henrik Lindman has studied a method of tailoring just the right dosage for each patient. This is done by measuring the decline in, above all, white corpuscles after each treatment and thereafter adjusting the following treatment. The method proved successful in the three different pioneering trials on women with breast cancer. The differences in tolerated chemotherapy were up to a factor of three across different patients, which, among other things, may be dependent on genetic differences in sensitivity. In a Nordic collaborative project, 525 women with breast cancer at high risk of recurrence were selected for treatment. Half of the patients received 9 doses of tailored treatment while the other half received high-dosage regimens with bone-marrow transplants after three standard dosages of chemotherapy. Patients receiving tailored treatment experienced a lower rate of recurrence of breast cancer (28% compared with 37% after 3 years).

The other two studies involved, respectively, 26 and 44 patients with metastasized breast cancer. Here, too, the effect of treatment was good in comparison with previous experience (81% and 63%, respectively, saw a dramatic reduction in their tumors). Women who could withstand the highest dosages did not experience more general side-effects than those who were given lower dosages.

Anneli Waara | alfa
Further information:
http://www.uu.se

More articles from Health and Medicine:

nachricht 'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS

nachricht New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

Im Focus: Autonomous 3D scanner supports individual manufacturing processes

Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).

Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Fingerprints of quantum entanglement

16.02.2018 | Information Technology

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers

16.02.2018 | Health and Medicine

Hubble sees Neptune's mysterious shrinking storm

16.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>