Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Advantages Of Rectal Vaccination Against HIV

15.12.2003


AIDS immunisation is still to be improved. Russian scientists suggest that rectal vaccination could be the most effective prevention of HIV transmission. The work is supported by the Interdepartmental Research and Technical Program "Vaccines of new generation and medical diagnostic systems of the future".



Researchers all over the world strive to obtain a vaccine preventing AIDS. Most promising are DNA-vaccines, which contain genes of human immunodeficiency virus. These genes function within the human body and synthesize certain viral proteins harmless to human health, and the immune system produces antibodies to those proteins and becomes resistible to a whole virus in case if the latter appears.

The DNA-vaccine is usually prescribed per-orally. One needs to eat quite a lot of DNA, which is very expensive, in order to induce an adequate immune response. Intramuscular injections can cause only a very weak and short-term response. Hence, scientists search for another route of DNA-vaccination that would require a low dose and provide a high specific immune response.


Karpenko and his colleagues from the Research Institute of Biological Engineering of the State Research Centre of Virology and Biotechnology "Vektor" (village Kol’tsovo in the Novosibirsk Region) and the Biological Medicine Centre (St. Petersburg) believe that rectal (anal) vaccination is superior to the other routes.

DNA-vaccine is packed into salmonella cells. Certain weakened strains of this bacterium are not dangerous for human health, but induce the generation of an additional immune barrier, which prevents HIV from penetrating through the mucous membrane into the body. The Russian research team constructed a plasmid carrying the gene of protein GP160 HIV-1 and packed it into salmonella cells. A suspension of these cells was given to mice.

Each mouse received a milliard of salmonellas (one drop of the suspension) either per-orally or per-rectally. All necessary control tests were performed as well. It was revealed that the vaccination does not damage mice’s health. A single treatment with salmonellas carrying DNA-vaccine is enough to induce the immune response: specific antibodies appear in the blood serum of all mice and suppress the HIV-1 development in the infected cell culture, and lymphocytes destroy the infected cells. But, the rectal vaccination induces a much stronger immune response than the oral one.

The researchers explain that as follows. Many of per-orally taken salmonellas perish in the stomach, and others cannot move further than the small intestine. They penetrate through certain cells of the intestine mucosa into lymph nodes and then spread throughout the body with the lymph. Rectal vaccination provides for the appearance of salmonellas in all parts of the intestine, particularly, in the colon having many lymph nodes.

Therefore, the per-rectal treatment makes it possible to use a low dose of vaccine, which is less disturbing for the body. The researchers believe that rectal route of immunisation using DNA-vaccine is quite promising in preventing HIV.

Sergey Komarov | Informnauka
Further information:
http://www.informnauka.ru

More articles from Health and Medicine:

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

nachricht Disrupted fat breakdown in the brain makes mice dumb
19.05.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

Im Focus: Hydrogen Bonds Directly Detected for the First Time

For the first time, scientists have succeeded in studying the strength of hydrogen bonds in a single molecule using an atomic force microscope. Researchers from the University of Basel’s Swiss Nanoscience Institute network have reported the results in the journal Science Advances.

Hydrogen is the most common element in the universe and is an integral part of almost all organic compounds. Molecules and sections of macromolecules are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

Media accreditation opens for historic year at European Health Forum Gastein

16.05.2017 | Event News

 
Latest News

New approach to revolutionize the production of molecular hydrogen

22.05.2017 | Materials Sciences

Scientists enlist engineered protein to battle the MERS virus

22.05.2017 | Life Sciences

Experts explain origins of topographic relief on Earth, Mars and Titan

22.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>