Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Use of antivirals by HIV-infected persons reduced their ability to infect partners

12.12.2003


The introduction and widespread use of highly active antiretroviral therapy (HAART) for HIV-infected persons in San Francisco in the late 1990s reduced their risks of infecting partners by 60 percent, according to a study conducted by researchers from the San Francisco Department of Public Health (SFDPH) and UCSF.



"While we found that antiretroviral use alone may account for a 60 percent reduction in risk of HIV transmission, a concurrent increase in risk behavior meant that rates of new infections did not decline sharply, but remained roughly stable for the period studied," said study lead investigator Travis Porco, PhD, MPH, an epidemiologist with SFDPH at the time the study was conducted.

The study, to be published in the January 2, 2004 issue of AIDS, analyzed data from 1994 to 1999 from the San Francisco Young Men’s Health Study (YMHS), which followed young gay men who were initially uninfected with HIV. Participants were asked about their sexual practices and tested for HIV at four follow-up visits, which included two before the widespread introduction of HAART for people with HIV in San Francisco and two later visits.


The study estimated the chances that a HIV-uninfected person would become infected by a sexual partner after factoring in sexual practice and condom use. Researchers found a per partnership decline of 60 percent in risk of becoming infected that occurred following the introduction and the widespread use of HAART by HIV-infected persons in San Francisco.

"Unfortunately, the doubling of the rate of unprotected receptive anal intercourse by study participants offset the beneficial effects of antiretroviral treatments becoming widely available," said study co-author and YMHS lead investigator, Dennis Osmond, PhD, UCSF professor in the Department of Epidemiology and Biostatistics.

"While our findings confirm that treatment of HIV-infected individuals can have quite a significant impact on the spread of AIDS, they also show that treatment needs to be accompanied by prevention interventions to reduce risky behavior in order to see the benefit in reduced rates of new HIV infections in the community," said Osmond.

Porco is currently senior epidemiologist with the Surveillance and Epidemiology Section of the Tuberculosis Control Branch of the California Department of Health Services. Other co-authors of the study are Jeffrey N. Martin, MD, MPH, assistant professor in the UCSF Department of Epidemiology and Biostatistics; Kimberly Page Shafer, PhD, MPH, assistant professor of medicine at the UCSF Center for AIDS Prevention Studies; Amber Cheng, MPH, statistician in the UCSF Department of Epidemiology and Biostatistics; Edwin Charlebois, PhD, MPH, assistant professor of medicine at the AIDS Policy Research Center at the UCSF AIDS Research Institute; and Robert M. Grant, MD, MPH, assistant investigator at the Gladstone Institute for Virology and Immunology and UCSF assistant professor of medicine.


The study was funded by grants from the National Institute on Drug Abuse, the National Cancer Institute, the National Institute of Dental and Craniofacial Research (all parts of the National Institutes of Health), the University-Wide AIDS Research Program of the State of California, the AIDS Clinical Research Center of the University of California, and the UCSF/Gladstone Institute for Virology and Immunology Center for AIDS Research

Jeff Sheehy | EurekAlert!
Further information:
http://www.ucsf.edu/

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>