Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Use of antivirals by HIV-infected persons reduced their ability to infect partners

12.12.2003


The introduction and widespread use of highly active antiretroviral therapy (HAART) for HIV-infected persons in San Francisco in the late 1990s reduced their risks of infecting partners by 60 percent, according to a study conducted by researchers from the San Francisco Department of Public Health (SFDPH) and UCSF.



"While we found that antiretroviral use alone may account for a 60 percent reduction in risk of HIV transmission, a concurrent increase in risk behavior meant that rates of new infections did not decline sharply, but remained roughly stable for the period studied," said study lead investigator Travis Porco, PhD, MPH, an epidemiologist with SFDPH at the time the study was conducted.

The study, to be published in the January 2, 2004 issue of AIDS, analyzed data from 1994 to 1999 from the San Francisco Young Men’s Health Study (YMHS), which followed young gay men who were initially uninfected with HIV. Participants were asked about their sexual practices and tested for HIV at four follow-up visits, which included two before the widespread introduction of HAART for people with HIV in San Francisco and two later visits.


The study estimated the chances that a HIV-uninfected person would become infected by a sexual partner after factoring in sexual practice and condom use. Researchers found a per partnership decline of 60 percent in risk of becoming infected that occurred following the introduction and the widespread use of HAART by HIV-infected persons in San Francisco.

"Unfortunately, the doubling of the rate of unprotected receptive anal intercourse by study participants offset the beneficial effects of antiretroviral treatments becoming widely available," said study co-author and YMHS lead investigator, Dennis Osmond, PhD, UCSF professor in the Department of Epidemiology and Biostatistics.

"While our findings confirm that treatment of HIV-infected individuals can have quite a significant impact on the spread of AIDS, they also show that treatment needs to be accompanied by prevention interventions to reduce risky behavior in order to see the benefit in reduced rates of new HIV infections in the community," said Osmond.

Porco is currently senior epidemiologist with the Surveillance and Epidemiology Section of the Tuberculosis Control Branch of the California Department of Health Services. Other co-authors of the study are Jeffrey N. Martin, MD, MPH, assistant professor in the UCSF Department of Epidemiology and Biostatistics; Kimberly Page Shafer, PhD, MPH, assistant professor of medicine at the UCSF Center for AIDS Prevention Studies; Amber Cheng, MPH, statistician in the UCSF Department of Epidemiology and Biostatistics; Edwin Charlebois, PhD, MPH, assistant professor of medicine at the AIDS Policy Research Center at the UCSF AIDS Research Institute; and Robert M. Grant, MD, MPH, assistant investigator at the Gladstone Institute for Virology and Immunology and UCSF assistant professor of medicine.


The study was funded by grants from the National Institute on Drug Abuse, the National Cancer Institute, the National Institute of Dental and Craniofacial Research (all parts of the National Institutes of Health), the University-Wide AIDS Research Program of the State of California, the AIDS Clinical Research Center of the University of California, and the UCSF/Gladstone Institute for Virology and Immunology Center for AIDS Research

Jeff Sheehy | EurekAlert!
Further information:
http://www.ucsf.edu/

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

 
Latest News

Scientists propose synestia, a new type of planetary object

23.05.2017 | Physics and Astronomy

Zap! Graphene is bad news for bacteria

23.05.2017 | Life Sciences

Medical gamma-ray camera is now palm-sized

23.05.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>