Bone marrow transplantation offers the hope of a complete cure for patients suffering from certain forms of cancer, such as leukemia or other immune deficiency diseases.
However, there is a risk that transplanted cells may recognize the recipient patients tissues as foreign and begin to attack them. This reaction, known as graft-versus-host disease (GVHD), can be lethal if it continues unchecked.
It has recently been shown in mice that the use of large numbers of immunoregulatory CD4+CD25+ T cells can induce tolerance to donor tissue following allogeneic hematopoietic stem cell transplantation and therefore control the development of GVHD.
Brooke Grindlinger | EurekAlert!
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