Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UC Riverside Researchers Publish Paper on Botulism Detection System

05.12.2003


Vladimir Parpura


Device Allows Early Detection of Botulism Toxins and More Effective Treatment

Researchers at the University of California, Riverside have developed a device that speeds the detection of a virulent strain of botulism neurotoxin from hours or days to minutes, making treatment or vaccination more effective.

Botulinum neurotoxin B, one of five strains that are known to be toxic to humans, is targeted in the paper that appeared in the Nov. 11 issue of the Proceedings of the National Academy of Sciences. The paper’s authors included UC Riverside Professor of Cell Biology and Neuroscience Vladimir Parpura and Umar Mohideen, a professor of physics, both part of the Center for Nanoscale Science and Engineering at UC Riverside; graduate student Wei Liu; staff researcher Vedrana Montana; and Edwin Chapman, a professor of physiology at the University of Wisconsin, Madison.



Given its rapid detection and small size, the device, known as a micromechanosensor, will find applications in medicine, in the war against bioterrorism or in the food industry, Parpura said.

“Of course a good deal of testing needs to be done first,” Parpura said. “What we’ve done is shown proof that the principle works.”

The principle, he added, works much like a fishing pole and line. A protein-coated bead at the end of a microscopic cantilever comes in contact with the neurotoxin, which cuts through the protein strands connecting the two, much like a fish would cut through a fishing line. The bead’s separation causes the cantilever to vibrate, announcing the neurotoxin’s presence. While effective, the process is not yet ready for practical application.

“Right now the issue is that it’s linked to an atomic-force microscope, an expensive piece of equipment, which means it cannot be used on a widespread basis,” Parpura said.

However, he holds out hope that the process could soon be put into wider practice to detect one of the most potent toxins known to man. The Centers for Disease Control and Prevention in Atlanta list botulism as one of the six most dangerous bioterrorism threats. Other such bio-threats include anthrax, plague and smallpox.

“The important thing to note is that the technique is very general and, in the future, can be done without the use of the atomic-force microscope. This also means that it will find uses in fields outside (medical) toxin sensors,” said Mohideen, adding that the process can be used in food and water quality applications.

The key to the process, however, is its timeliness, according to the researchers. Antitoxin vaccinations can work only if applied quickly, before the onset of symptoms. Symptoms of food-borne botulism intoxication frequently take from 12 to 36 hours to develop, according to the CDC.

“When you think that we’ve cut the detection time from a few hours or a couple of days, down to a few minutes, that’s what’s important,” Parpura said. “The shorter the detection time, the more time you have to treat people and that makes a great deal of difference when dealing with this neurotoxin.”

“We are working on approaches to further reduce the detection time and substantially improve the sensitivity,” Mohideen added.

Botulism, while rare in the United States, is considered a medical emergency in which roughly 10 percent of those afflicted die. Those who survive may take weeks or months to recover and frequently undergo intensive hospital care with extensive use of ventilators.

Ricardo Duran | UC Riverside
Further information:
http://www.newsroom.ucr.edu/cgi-bin/display.cgi?id=707

More articles from Health and Medicine:

nachricht Finnish research group discovers a new immune system regulator
23.02.2018 | University of Turku

nachricht Minimising risks of transplants
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Attoseconds break into atomic interior

A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.

In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...

Im Focus: Good vibrations feel the force

A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.

By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Basque researchers turn light upside down

23.02.2018 | Physics and Astronomy

Finnish research group discovers a new immune system regulator

23.02.2018 | Health and Medicine

Attoseconds break into atomic interior

23.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>