Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New understanding of nervous system gives insight into common gut problem in newborn babies

04.12.2003


Medical Research Council (MRC) researchers have unlocked the mysteries of the nervous system responsible for proper formation and function of the gut. This new understanding has implications for treating Hirschsprung’s disease, a common disorder in newborns that requires corrective surgery in order for food to pass through the bowel and the colon.



The study shows that two important molecular switches work together to regulate the movement of crucially important cells, that will eventually become ‘enteric neurons.’ During early embryonic development these cells move from the brain to the gut, to create the ‘enteric’ nervous system. This specialised branch of the nervous system works independently of the brain and is responsible for ‘peristalsis’ of the gut – the wave-like contraction of the gut that allows the contents to be propelled through the bowel.

Failure of these migrating cells to populate the entire length of the gut causes Hirschprung’s disease, a common disorder that affects approximately one in every 4500 children. The affected portion does not expand and the contents of the bowel accumulate in the upper colon, causing swelling, abdominal pain and severe constipation, which could have serious consequences if left untreated.


The team, led by Professor Vassilis Pachnis at the MRC National Institute for Medical Research, found that some of the key molecules* that are individually important for development of the enteric nervous system, work together to act as master regulators to allow normal colonisation of the gut by the enteric neurons.

The researchers also found that the balance of both these key molecules is critical to correct development and function of the gut.

Professor Pachnis said: “The work we’ve been doing is very basic and doesn’t offer an immediate alternative to surgery, which is used successfully at the moment to alleviate the immediate effects of obstruction. However, frequently, and despite successful surgery Hirschsprung’s patients continue to have associated problems throughout life.

“By modifying defective versions of these molecules, so the enteric neurons can establish themselves appropriately along the full length of the gut, it might be possible to prevent this common problem and remove the need for surgery in future. We’re already looking at how stem-cell technology could help us in this approach.”

| alfa
Further information:
http://www.biologists.com/web/index.html
http://www.mrc.ac.uk

More articles from Health and Medicine:

nachricht Nanoparticles as a Solution against Antibiotic Resistance?
15.12.2017 | Friedrich-Schiller-Universität Jena

nachricht Plasmonic biosensors enable development of new easy-to-use health tests
14.12.2017 | Aalto University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Error-free into the Quantum Computer Age

A study carried out by an international team of researchers and published in the journal Physical Review X shows that ion-trap technologies available today are suitable for building large-scale quantum computers. The scientists introduce trapped-ion quantum error correction protocols that detect and correct processing errors.

In order to reach their full potential, today’s quantum computer prototypes have to meet specific criteria: First, they have to be made bigger, which means...

Im Focus: Search for planets with Carmenes successful

German and Spanish researchers plan, build and use modern spectrograph

Since 2016, German and Spanish researchers, among them scientists from the University of Göttingen, have been hunting for exoplanets with the “Carmenes”...

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

The body's street sweepers

18.12.2017 | Life Sciences

Fast flowing heat in layered material heterostructures

18.12.2017 | Materials Sciences

Life on the edge prepares plants for climate change

18.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>