Medical Research Council (MRC) researchers have unlocked the mysteries of the nervous system responsible for proper formation and function of the gut. This new understanding has implications for treating Hirschsprung’s disease, a common disorder in newborns that requires corrective surgery in order for food to pass through the bowel and the colon.
The study shows that two important molecular switches work together to regulate the movement of crucially important cells, that will eventually become ‘enteric neurons.’ During early embryonic development these cells move from the brain to the gut, to create the ‘enteric’ nervous system. This specialised branch of the nervous system works independently of the brain and is responsible for ‘peristalsis’ of the gut – the wave-like contraction of the gut that allows the contents to be propelled through the bowel.
Failure of these migrating cells to populate the entire length of the gut causes Hirschprung’s disease, a common disorder that affects approximately one in every 4500 children. The affected portion does not expand and the contents of the bowel accumulate in the upper colon, causing swelling, abdominal pain and severe constipation, which could have serious consequences if left untreated.
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Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
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Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.
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Scientists from the MPI for Chemical Energy Conversion report in the first issue of the new journal JOULE.
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