Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New standard for voice saving care of larynx cancer patients

27.11.2003


Results of a national clinical trial confirm that simultaneous treatment with chemotherapy and radiation preserves the voice of patients with advanced larynx cancer without compromising survival rates. The findings, reported in the November 27, 2003 issue of the New England Journal of Medicine are compelling enough to have the combination treatment become the standard of care for such patients, the study’s authors report.



"Chemotherapy and radiation together are recommended for advanced laryngeal cancer patients who are otherwise in good health and want to preserve their voice," says Arlene Forastiere, M.D., professor of oncology and otolaryngology at the Johns Hopkins Kimmel Cancer Center and chair of the study. "For patients who have other significant medical problems or little support at home, we would recommend radiation alone. In all cases, patients should be followed closely during treatment by a head and neck surgeon, so that surgery can be performed if there is residual or recurrent cancer after treatment." This year, approximately 9,500 Americans will be diagnosed with laryngeal cancer and 3,800 will die from the disease.

Experience with combined treatment, Forastiere adds, has reduced the need for complete removal of the larynx from 100 percent to about 15 percent. Removing the larynx leaves patients unable to speak with their natural voice and typically use speaking aids such as an electronic device. Other previously-studied treatment options included radiation therapy alone or several cycles of chemotherapy followed by radiation. Studies from a decade ago showed that the survival rate of patients treated with chemotherapy followed by radiation was just as good as those receiving surgery.


This new study of 547 patients shows that giving chemotherapy and radiation together instead of sequentially is more effective in preserving the voice box. 88 percent of patients receiving chemotherapy and radiation together still had their voice box after two years as compared to 75 percent receiving chemotherapy followed by radiation and 70 percent receiving radiation alone. For each of these three treatment options, overall survival was similar at about 75 percent after two years.

"Giving chemotherapy with radiation at the same time makes cancer cells more susceptible to radiation, so effectively more tumor cells are destroyed," explains Forastiere.

The national study was conducted through centers participating in the Radiation Therapy Oncology Group (RTOG), the Southwest Oncology Group (SWOG), the Eastern Cooperative Oncology Group (ECOG) and was funded by the National Cancer Institute.

Other research participants included Helmuth Goepfert, M.D., Moshe Maor, M.D., Randal Weber, M.D., William Morrison, M.D., Bonnie Glisson, M.D., from the University of Texas M.D. Anderson Cancer Center; Thomas F. Pajak, Ph.D., from the RTOG; Andy Trotti, M.D., from the H. Lee Moffitt Cancer Center and Research Institute; John A. Ridge, M.D., Ph.D., from the Fox Chase Cancer Center; Glen Peters, M.D., from the University of Alabama; Andrea Leaf, M.D., from the New York Harbor Healthcare System; John Ensley, M.D., from the Karmanos Cancer Institute at Wayne State University School of Medicine; Jay Cooper, M.D., from New York University Medical Center and Ding-Jen Lee, M.D., Ph.D., from the Johns Hopkins Kimmel Cancer Center.

Vanessa Wasta | EurekAlert!
Further information:
http://www.hopkinsmedicine.org/
http://www.hopkinskimmelcancercenter.org

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Strathclyde-led research develops world's highest gain high-power laser amplifier

The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.

The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Camera on NASA's Lunar Orbiter survived 2014 meteoroid hit

29.05.2017 | Physics and Astronomy

Strathclyde-led research develops world's highest gain high-power laser amplifier

29.05.2017 | Physics and Astronomy

A 3-D look at the 2015 El Niño

29.05.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>