Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Hassle-free stroke prevention offered by new drug, Stanford researcher says

21.11.2003


People who take a commonly prescribed yet problematic drug called Coumadin to prevent stroke or blood clots may soon have a hassle-free alternative, according to research at Stanford University School of Medicine. Results from a 7,329-person international study have found that a new drug called ximelegatran prevents strokes as effectively as Coumadin without the side effects or inconvenience.



"We think this will result in a huge shift in anti-coagulation therapy," said Gregory Albers, MD, professor of neurology and neurological sciences and director of the Stanford Stroke Center. Albers was a member of the steering committee that designed and directed the trial. Results from the 3,407-person international phase of the study will be published in the Nov. 22 issue of The Lancet. Albers and his colleagues presented results from the 3,922-person North American study at the American Heart Association meeting Nov. 11 in Orlando.

Coumadin effectively thins the blood and prevents strokes in people with a type of erratic heartbeat called atrial fibrillation. The problem is that the drug has a very narrow effective dose range – too little and it doesn’t work, too much and a person bleeds excessively. The drug also interacts with other medications and with food. Because of these complications, people on Coumadin must have their blood checked and dose adjusted regularly to make sure they are protected from stroke.


"Coumadin is very effective, but more than half of the people who should be receiving it don’t take the medication because of the inconvenience," Albers said.

In contrast, ximelegatran is just as effective as Coumadin but doesn’t require blood tests for dose adjustment and doesn’t interact with medications or food. "It’s essentially one-dose-fits-all," Albers said.

Called the Stroke Prevention Using an Oral Thrombin Inhibitor in Atrial Fibrillation, or SPORTIF, the studies comparing ximelegatran to Coumadin took place in 25 countries. They included 7,329 patients who were treated with one of the two drugs for an average of nearly two years. These were the largest trials ever conducted on people with atrial fibrillation, Albers said.

During the trials, people in the two groups had similar rates of stroke or death, though those taking ximelegatran had fewer major bleeding incidents. Albers said the most important difference was that patients on Coumadin required constant dose adjustment while those on ximelegatran took the same dose throughout the trial.

Albers said that about 6 percent of people on ximelegatran had elevated levels of liver enzymes in the period between two to six months of treatment. This side effect usually disappeared without any consequences, but he said people on ximelegatran will need to have their liver function monitored during the first few months of therapy.

Albers said he expects ximelegatran to be approved by the U.S. Food and Drug Administration within the next year. It will be sold by the pharmaceutical company AstraZeneca under the brand name Exanta. Albers served as a consultant for AstraZeneca during the trial.


Stanford University Medical Center integrates research, medical education and patient care at its three institutions – Stanford University School of Medicine, Stanford Hospital & Clinics and Lucile Packard Children’s Hospital at Stanford. For more information, please visit the Web site of the medical center’s Office of Communication & Public Affairs at http://mednews.stanford.edu.

Amy Adams | EurekAlert!
Further information:
http://mednews.stanford.edu

More articles from Health and Medicine:

nachricht Custom-tailored strategy against glioblastomas
26.09.2016 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New leukemia treatment offers hope
23.09.2016 | King Abdullah University of Science and Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: OLED microdisplays in data glasses for improved human-machine interaction

The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.

“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...

Im Focus: Artificial Intelligence Helps in the Discovery of New Materials

With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.

Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...

Im Focus: Complex hardmetal tools out of the 3D printer

For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.

Fraunhofer IKTS counts decades of proven expertise in the development of hardmetals. To date, reliable cutting, drilling, pressing and stamping tools made of...

Im Focus: Launch of New Industry Working Group for Process Control in Laser Material Processing

At AKL’16, the International Laser Technology Congress held in May this year, interest in the topic of process control was greater than expected. Appropriately, the event was also used to launch the Industry Working Group for Process Control in Laser Material Processing. The group provides a forum for representatives from industry and research to initiate pre-competitive projects and discuss issues such as standards, potential cost savings and feasibility.

In the age of industry 4.0, laser technology is firmly established within manufacturing. A wide variety of laser techniques – from USP ablation and additive...

Im Focus: New laser joining technologies at ‘K 2016’ trade fair

Every three years, the plastics industry gathers at K, the international trade fair for plastics and rubber in Düsseldorf. The Fraunhofer Institute for Laser Technology ILT will also be attending again and presenting many innovative technologies, such as for joining plastics and metals using ultrashort pulse lasers. From October 19 to 26, you can find the Fraunhofer ILT at the joint Fraunhofer booth SC01 in Hall 7.

K is the world’s largest trade fair for the plastics and rubber industry. As in previous years, the organizers are expecting 3,000 exhibitors and more than...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Experts from industry and academia discuss the future mobile telecommunications standard 5G

23.09.2016 | Event News

ICPE in Graz for the seventh time

20.09.2016 | Event News

Using mathematical models to understand our brain

16.09.2016 | Event News

 
Latest News

How to merge two black holes in a simple way

26.09.2016 | Physics and Astronomy

Australian technology installed on world’s largest single-dish radio telescope

26.09.2016 | Physics and Astronomy

New mechanisms uncovered explaining frost tolerance in plants

26.09.2016 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>