Combining radiation with an agent that blocks VEGF, a protein that promotes the development of blood vessels and the growth of cancerous tumors – a process known as angiogenesis – may be more effective against brain tumors than either treatment alone, researchers at Jefferson Medical College have found.
Scientists led by Phyllis Wachsberger, Ph.D., assistant professor of radiation oncology at Jefferson Medical College of Thomas Jefferson University in Philadelphia, and Adam Dicker, M.D., associate professor of radiation oncology at Jefferson Medical College, looked at whether adding radiation changed the effectiveness of a drug called VEGF Trap on the growth of a common brain tumor, glioblastoma, in a mouse model. VEGF Trap is a protein engineered to block VEGF activity. The particular type of brain tumor expresses high levels of VEGF and is resistant to treatment with many other antiangiogenic drugs.
According to Dr. Dicker, who is also director of the Division of Experimental Radiation Oncology at Jefferson’s Kimmel Cancer Center, the findings indicate that radiation may in many cases substantially enhance the drug’s anti-tumor activity. In fact, research results from Jefferson and other laboratories indicate that VEGF Trap may be as much as 1,000 times more potent in controlling cancerous tumor growth than angiogenesis inhibitors now under review by the Food and Drug Administration, he says.
Steven Benowitz | TJUH
Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
28.04.2017 | Event News
20.04.2017 | Event News
18.04.2017 | Event News
28.04.2017 | Medical Engineering
28.04.2017 | Earth Sciences
28.04.2017 | Life Sciences