Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Leading the way in novel anti-cancer research

19.11.2003


Key AstraZeneca data presented at the AACR-NCI-EORTC meeting



New research presented today at an official AACR-NCI-EORTC* press conference highlights the potential of a new approach to fighting cancer -- inhibition of Aurora kinases. The study, carried out by AstraZeneca, represents part of a body of innovative research and discovery work undertaken by the company as part of a broad based development program of novel cancer therapies. Key research presented this week also includes results from a study combining two agents developed by AstraZeneca: an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor and the vascular targeting agent ZD6126.

New frontiers in cancer biology – inhibition of Aurora kinases:


The Aurora kinase family is important in regulating mitosis and cell division. Because these kinases are only expressed in cells that are actively dividing, they could be an important new target in cancer. Aurora kinases are commonly over expressed in breast, colon, pancreas and bladder tumors and this is correlated with poor prognosis in these diseases. AstraZeneca scientists have discovered selective and potent inhibitors of Aurora kinase activity that may have potential application in human cancer treatment. These inhibitors of Aurora kinase are being investigated to ascertain their potential in the treatment of cancer.

"Through cutting-edge research and development, AstraZeneca hopes to achieve a better understanding of Aurora kinases and their regulation, which could in time be a basis for treating or even preventing cancer," said George Blackledge, Vice President, Medical Director of Oncology, AstraZeneca. "This is part of a broad based development program in cell cycle directed therapies."

Leading the way in combining novel anti-cancer approaches:

New pre-clinical research presented at the meeting shows that combining a vascular targeting agent with an EGFR tyrosine kinase inhibitor may result in greater anti-tumor activity than either agent alone. These agents attack the tumor by different mechanisms.

Tumor blood vessels differ significantly from normal blood vessels. The endothelial cells which line their vessel walls retain the characteristics of immature, newly formed dividing cells and appear to depend heavily on a tubulin cytoskeleton to maintain their shape. Vascular targeting agents are designed to disrupt this cytoskeleton, causing the endothelial cells to change shape from flat to round, resulting in damage to the blood vessel lining. This causes vessel congestion and cessation of blood flow. The tumor is thus starved of oxygen and nutrients, while its waste products start to build up to toxic levels. As a result, much of the tumor dies.

The potential of ZD6126, a vascular targeting agent, and an EGFR tyrosine kinase inhibitor to work together in combination as a cancer treatment approach was evaluated in preclinical work being presented today at this meeting. Based on the results seen in these models, clinical investigation of this drug combination is about to begin.

Also presented at the meeting, University of Florida medical scientists reported the results of the combination of ZD6126 with another AstraZeneca novel anticancer agent in development known as ZD6474, an anti-angiogenesis agent. Anti-angiogenesis agents being developed by AstraZeneca are designed to block the vascular endothelial growth factor (VEGF) signaling pathway. This pathway is a critical step in angiogenesis, the process by which tumors stimulate the formation of new blood vessels. Based on results from preclinical studies, clinical investigations of the combination of vascular targeting agents and anti-angiogenesis agents are planned.

Other novel approaches:

AstraZeneca has a broad portfolio of novel cancer agents in early development for the potential treatment of a wide range of tumors. New pre-clinical data on several AstraZeneca novel agents have been presented at the AACR/NCI/EORTC meeting in Boston this week:
  • An oral prenylation inhibitor treatment that prevents the activation of a number of growth promoting proteins and thus prevents cancer cells from dividing (proliferating)
  • An orally active Src kinase inhibitor, which reduces the ability of cancer cells to invade normal tissues, preventing tumors from spreading
  • CDK (cyclin dependent kinase) and Aurora kinase inhibitors, which interfere with crucial steps in cell division and inhibit the proliferation of cancer cells

About AstraZeneca:

AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. It is one of the top five pharmaceutical companies in the world with healthcare sales of over $17.8 billion and leading positions in sales of gastrointestinal, oncology, cardiovascular, neuroscience and respiratory products. In the United States, AstraZeneca is a $9.3 billion healthcare business with more than 12,000 employees. AstraZeneca is listed in the Dow Jones Sustainability Index (Global and European) as well as the FTSE4Good Index.

For more information about AstraZeneca, please visit www.astrazeneca-us.com

*AACR: American Association for Cancer Research; NCI: National Cancer Institute; EORTC: European Organization for Research and Treatment of Cancer.

Emily Denney | EurekAlert!
Further information:
http://www.astrazeneca.com/

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>