Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

High nuclear grade associated with recurrence of in situ breast lesions

19.11.2003


Women with ductal carcinoma in situ, a non-invasive form of breast cancer, are more likely to experience a recurrence after treatment if their DCIS is of a high nuclear grade or is detected by palpation during a breast examination, according to a study in the November 19 issue of the Journal of the National Cancer Institute.



DCIS accounts for about 20% of all newly diagnosed cases of breast cancer in the United States and is initially treated surgically, either by mastectomy (removal of the entire breast) or lumpectomy (removal of the tumor and minimal surrounding tissue). Some women will experience a recurrence, but it is unclear what characteristics are associated with the risk of recurrence.

Karla Kerlikowske, M.D., of the San Francisco Veterans Affairs Medical Center, and her colleagues examined information about 1,036 women in the San Francisco Bay area who were age 40 or older when diagnosed with DCIS and treated with lumpectomy alone.


During a median follow-up of 6.5 years, 209 women (20.2%) experienced a recurrence, either as DCIS (10.8%) or as invasive cancer (9.4%). The researchers compared tumor characteristics--including nuclear grade (the size and shape of the nucleus in tumor cells) and tumor margin width--of the women who had a recurrence with those of a random sample of women who did not have a recurrence.

Women with high-nuclear-grade lesions had a 5-year risk of an invasive recurrence of 11.8%, compared with 4.8% for women with low-nuclear-grade lesions. Although most of the cases (80%) of DCIS were initially detected by mammography, women with initial lesions detected by palpation were more likely to develop recurrence as invasive cancer than women with lesions detected by mammography.

The authors say that women with high-nuclear-grade DCIS or those with DCIS detected by palpation and who are treated by lumpectomy alone may be appropriate candidates for adjuvant therapy, adding that longer follow-up is necessary to confirm their findings. In addition, they note that "further study is needed to examine whether measurements of molecular markers can further help estimate an individual’s risk for recurrence to avoid over- and undertreatment of women with DCIS."


Contact: Eve Harris, University of California San Francisco Cancer Center, 415-885-7277; fax: 415-353-9241, eharris@pubaff.ucsf.edu.

Kerlikowske K, Molinaro A, Cha I, Ljung B, Ernster VL, Stewart K, et al. Characteristics associated with recurrence among women with ductal carcinoma in situ treated by lumpectomy. J Natl Cancer Inst 2003;95:1692–1702.

Note: The Journal of the National Cancer Institute is published by Oxford University Press and is not affiliated with the National Cancer Institute. Attribution to the Journal of the National Cancer Institute is requested in all news coverage.

Linda Wang | EurekAlert!
Further information:
http://jncicancerspectrum.oupjournals.org/

More articles from Health and Medicine:

nachricht Cholesterol-lowering drugs may fight infectious disease
22.08.2017 | Duke University

nachricht Once invincible superbug squashed by 'superteam' of antibiotics
22.08.2017 | University at Buffalo

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

What the world's tiniest 'monster truck' reveals

23.08.2017 | Life Sciences

Treating arthritis with algae

23.08.2017 | Life Sciences

Witnessing turbulent motion in the atmosphere of a distant star

23.08.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>