A new signaling pathway appears to play a critical role in the development of heart disease, according to researchers at Stanford University School of Medicine. Now that this marker of cardiac dysfunction, known as the APJ-apelin pathway, has been identified, it could lead to better diagnosis of heart problems, perhaps even allowing doctors to intervene in heart disease by blocking or boosting levels of critical proteins.
"The thing that’s clear is that apelin is increased in heart failure," said Euan Ashley, MD, PhD, a clinical fellow in cardiovascular medicine and one of the lead authors of the study, which is being presented at a Nov. 12 poster session at the annual American Heart Association meeting in Orlando.
"The idea of a blood test to help make a diagnosis of heart disease is very appealing," Ashley said. "But my bigger hope is for therapeutic potential, and given what we know about apelin levels changing a lot during heart failure, either blocking or enhancing this system may provide a treatment for heart failure."
Mitzi Baker | EurekAlert!
World first: Massive thrombosis removed during early pregnancy
20.07.2017 | Universitätsspital Bern
Therapy of preterm birth in sight?
19.07.2017 | Universitätsspital Bern
Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.
For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...
What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.
To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...
The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....
A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...
Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision
Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...
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