Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Growth factor grows stem cells that help heal hearts

12.11.2003


American Heart Association meeting report



A drug that stimulates bone marrow to produce stem cells helped regenerate damaged heart muscle in one of the first studies of its kind, according to a report presented at the American Heart Association’s Scientific Sessions 2003.

The drug, granulocyte colony stimulating factor (G-CSF), treats some forms of cancer. It stimulates bone marrow to produce the different types of blood cells, including white blood cells that can become depleted after disease or chemotherapy.


G-CSF might help repopulate the heart’s muscle cells, which in turn could help repair the damaged heart, said lead author Chris A. Glover, M.D.

"Research has shown that there are cells in the heart that come from bone marrow stem cells. We hypothesized increasing these cells after a heart attack may help the heart regenerate heart muscle cells, and this is supported by our results," said Glover, assistant professor of medicine at the University of Ottawa and the Ottawa Heart Institute in Ontario.

"The main limitation of this study is that it included only five patients and was not randomized. On the other hand, the study’s strengths are that it explores the use of a novel therapy, which is a simple treatment that any physician could use to improve the outlook for heart attack patients."

All five patients who received G-CSF had anterior wall heart attacks, also known as large heart attacks. They had emergency angioplasty, a procedure to open their vessels by inserting an inflatable balloon that compresses the plaque and restores blood flow.

"We wanted patients with large heart attacks in this study, since they have the most to benefit from a therapy that could regenerate the heart," Glover said.

Within two weeks of the patients’ heart attack, doctors injected G-CSF in the fatty skin layers once a day for four consecutive days.

Researchers measured CD34 cells, a marker of stem cells, to find out if the drug was stimulating stem cell growth. An increase in white blood cells indirectly indicates that G-CSF is working. After four days, blood cells increased about five-fold and CD34 cells increased about 10-fold. Before treatment and six weeks after treatment, researchers also measured left ventricular (LV) ejection fraction, which indicates how much blood the heart pumps out of its main chamber. They assessed blood flow and metabolism by positron emission tomography (PET) scan, which measures the heart’s contraction and indicates how much heart tissue is viable.

All five patients were free of side effects or heart-related complications at six weeks’ follow-up. Also at six weeks, ejection fraction went from 27 percent to 35 percent, and the patients had a considerable metabolic (viable tissue) recovery from 59 percent to 75 percent.


Co-authors are R.S. Beanlands; R.A. deKemp; K. Mostert; L. Garrard and H. Atkins.

Carole Bullock | EurekAlert!
Further information:
http://www.americanheart.org/

More articles from Health and Medicine:

nachricht Speed data for the brain’s navigation system
06.12.2016 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE)

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Simple processing technique could cut cost of organic PV and wearable electronics

06.12.2016 | Materials Sciences

3-D printed kidney phantoms aid nuclear medicine dosing calibration

06.12.2016 | Medical Engineering

Robot on demand: Mobile machining of aircraft components with high precision

06.12.2016 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>