Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Growth factor grows stem cells that help heal hearts

12.11.2003


American Heart Association meeting report



A drug that stimulates bone marrow to produce stem cells helped regenerate damaged heart muscle in one of the first studies of its kind, according to a report presented at the American Heart Association’s Scientific Sessions 2003.

The drug, granulocyte colony stimulating factor (G-CSF), treats some forms of cancer. It stimulates bone marrow to produce the different types of blood cells, including white blood cells that can become depleted after disease or chemotherapy.


G-CSF might help repopulate the heart’s muscle cells, which in turn could help repair the damaged heart, said lead author Chris A. Glover, M.D.

"Research has shown that there are cells in the heart that come from bone marrow stem cells. We hypothesized increasing these cells after a heart attack may help the heart regenerate heart muscle cells, and this is supported by our results," said Glover, assistant professor of medicine at the University of Ottawa and the Ottawa Heart Institute in Ontario.

"The main limitation of this study is that it included only five patients and was not randomized. On the other hand, the study’s strengths are that it explores the use of a novel therapy, which is a simple treatment that any physician could use to improve the outlook for heart attack patients."

All five patients who received G-CSF had anterior wall heart attacks, also known as large heart attacks. They had emergency angioplasty, a procedure to open their vessels by inserting an inflatable balloon that compresses the plaque and restores blood flow.

"We wanted patients with large heart attacks in this study, since they have the most to benefit from a therapy that could regenerate the heart," Glover said.

Within two weeks of the patients’ heart attack, doctors injected G-CSF in the fatty skin layers once a day for four consecutive days.

Researchers measured CD34 cells, a marker of stem cells, to find out if the drug was stimulating stem cell growth. An increase in white blood cells indirectly indicates that G-CSF is working. After four days, blood cells increased about five-fold and CD34 cells increased about 10-fold. Before treatment and six weeks after treatment, researchers also measured left ventricular (LV) ejection fraction, which indicates how much blood the heart pumps out of its main chamber. They assessed blood flow and metabolism by positron emission tomography (PET) scan, which measures the heart’s contraction and indicates how much heart tissue is viable.

All five patients were free of side effects or heart-related complications at six weeks’ follow-up. Also at six weeks, ejection fraction went from 27 percent to 35 percent, and the patients had a considerable metabolic (viable tissue) recovery from 59 percent to 75 percent.


Co-authors are R.S. Beanlands; R.A. deKemp; K. Mostert; L. Garrard and H. Atkins.

Carole Bullock | EurekAlert!
Further information:
http://www.americanheart.org/

More articles from Health and Medicine:

nachricht Nanoparticles as a Solution against Antibiotic Resistance?
15.12.2017 | Friedrich-Schiller-Universität Jena

nachricht Plasmonic biosensors enable development of new easy-to-use health tests
14.12.2017 | Aalto University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>