Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Growth factor grows stem cells that help heal hearts

12.11.2003


American Heart Association meeting report



A drug that stimulates bone marrow to produce stem cells helped regenerate damaged heart muscle in one of the first studies of its kind, according to a report presented at the American Heart Association’s Scientific Sessions 2003.

The drug, granulocyte colony stimulating factor (G-CSF), treats some forms of cancer. It stimulates bone marrow to produce the different types of blood cells, including white blood cells that can become depleted after disease or chemotherapy.


G-CSF might help repopulate the heart’s muscle cells, which in turn could help repair the damaged heart, said lead author Chris A. Glover, M.D.

"Research has shown that there are cells in the heart that come from bone marrow stem cells. We hypothesized increasing these cells after a heart attack may help the heart regenerate heart muscle cells, and this is supported by our results," said Glover, assistant professor of medicine at the University of Ottawa and the Ottawa Heart Institute in Ontario.

"The main limitation of this study is that it included only five patients and was not randomized. On the other hand, the study’s strengths are that it explores the use of a novel therapy, which is a simple treatment that any physician could use to improve the outlook for heart attack patients."

All five patients who received G-CSF had anterior wall heart attacks, also known as large heart attacks. They had emergency angioplasty, a procedure to open their vessels by inserting an inflatable balloon that compresses the plaque and restores blood flow.

"We wanted patients with large heart attacks in this study, since they have the most to benefit from a therapy that could regenerate the heart," Glover said.

Within two weeks of the patients’ heart attack, doctors injected G-CSF in the fatty skin layers once a day for four consecutive days.

Researchers measured CD34 cells, a marker of stem cells, to find out if the drug was stimulating stem cell growth. An increase in white blood cells indirectly indicates that G-CSF is working. After four days, blood cells increased about five-fold and CD34 cells increased about 10-fold. Before treatment and six weeks after treatment, researchers also measured left ventricular (LV) ejection fraction, which indicates how much blood the heart pumps out of its main chamber. They assessed blood flow and metabolism by positron emission tomography (PET) scan, which measures the heart’s contraction and indicates how much heart tissue is viable.

All five patients were free of side effects or heart-related complications at six weeks’ follow-up. Also at six weeks, ejection fraction went from 27 percent to 35 percent, and the patients had a considerable metabolic (viable tissue) recovery from 59 percent to 75 percent.


Co-authors are R.S. Beanlands; R.A. deKemp; K. Mostert; L. Garrard and H. Atkins.

Carole Bullock | EurekAlert!
Further information:
http://www.americanheart.org/

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Researchers release the brakes on the immune system

18.10.2017 | Health and Medicine

Separating methane and CO2 will become more efficient

18.10.2017 | Life Sciences

Ocean atmosphere rife with microbes

17.10.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>