Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Bone marrow stem cells build new circulation to lungs

11.11.2003


American Heart Association meeting report



A bone marrow stem cell transplant restored circulation to injured blood vessels in animals with pulmonary hypertension, according to a study presented today at the American Heart Association’s Scientific Sessions 2003.

“This is a novel and exciting approach,” said Duncan Stewart, M.D., professor and director of cardiology at the University of Toronto and head of cardiology at St. Michael’s Hospital. Pulmonary arterial hypertension (PAH) is abnormally high blood pressure in the arteries between the heart and lungs. It is a progressive disease that can affect the arterioles and capillaries that supply blood to the lungs.


“PAH reduces the heart’s ability to pump blood through the lungs and gradually leads to heart failure. Today, we can achieve some improvement with drugs, but the treatment is palliative and can only delay death,” Stewart said.

Restoring blood flow to the lungs with a stem cell transplant in the pulmonary vessels may hold promise as a new treatment for PAH, Stewart said.

His team used endothelial progenitor cells. Endothelial cells form a thin lining in blood vessels, providing an interface between the vessel and blood. This lining, called the endothelium, regulates a host of basic processes, such as blood clotting and blood pressure.

“Our results show that endothelial progenitor cells from the bone marrow circulate in the bloodstream. We can use them to form new blood vessels or repair damaged ones,” Stewart said. Stewart and co-investigator Yidan Zhao, M.D., a research associate at the University of Toronto and St. Michael’s Hospital, removed vascular progenitor cells from rats’ bone marrow. The cells were cultured for five days, then injected into the pulmonary circulation of rats with PAH. A second group of rats with PAH received skin fibroblasts (cells), while a third group, which did not have PAH, were used as controls.

Right ventricular systolic blood pressure (the pressure when the heart contracts) was measured 21 days later. The systolic pressure of the untreated, normal rats was 26 millimeters of mercury (mm Hg). Rats with PAH had a systolic pressure of 47 mm Hg. Systolic pressure fell to 32 mm Hg in those treated with endothelial progenitor cells, and it was relatively unchanged (45 mm Hg) in control animals treated with skin fibroblasts.

In some experiments, the endothelial progenitor cells were labeled with a fluorescent marker. An imaging technique called fluorescent microangiography was used to look at these cells to determine if microcirculation in the pulmonary vessels had been restored.

“The cells could be seen engrafting into the microcirculation and forming tiny new blood vessels,” Zhao said. “In the treated rats, microcirculation in the lungs was restored to almost normal levels, while severe PAH was observed in untreated animals and those that received skin fibroblasts.”

The stem cell group also had a reduction in thickening of the heart wall. This indicated, that the cells were not only repairing the smaller vessels, but there were also improvements in larger vessels.

“We found a regenerative approach that could lead to a new clinical therapy for this devastating disease in the quite-near future,” he said.


Co-authors are Y. D. Zhao, M.D., Ph.D.; Y. Deng, M.D.; Q. Zhang M.D., Ph.D.; L. Kugathasan, B.Sc. and D.W. Courtman, Ph.D.

Carole Bullock | EurekAlert!
Further information:
http://www.americanheart.org/

More articles from Health and Medicine:

nachricht Custom-tailored strategy against glioblastomas
26.09.2016 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New leukemia treatment offers hope
23.09.2016 | King Abdullah University of Science and Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: OLED microdisplays in data glasses for improved human-machine interaction

The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.

“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...

Im Focus: Artificial Intelligence Helps in the Discovery of New Materials

With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.

Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...

Im Focus: Complex hardmetal tools out of the 3D printer

For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.

Fraunhofer IKTS counts decades of proven expertise in the development of hardmetals. To date, reliable cutting, drilling, pressing and stamping tools made of...

Im Focus: Launch of New Industry Working Group for Process Control in Laser Material Processing

At AKL’16, the International Laser Technology Congress held in May this year, interest in the topic of process control was greater than expected. Appropriately, the event was also used to launch the Industry Working Group for Process Control in Laser Material Processing. The group provides a forum for representatives from industry and research to initiate pre-competitive projects and discuss issues such as standards, potential cost savings and feasibility.

In the age of industry 4.0, laser technology is firmly established within manufacturing. A wide variety of laser techniques – from USP ablation and additive...

Im Focus: New laser joining technologies at ‘K 2016’ trade fair

Every three years, the plastics industry gathers at K, the international trade fair for plastics and rubber in Düsseldorf. The Fraunhofer Institute for Laser Technology ILT will also be attending again and presenting many innovative technologies, such as for joining plastics and metals using ultrashort pulse lasers. From October 19 to 26, you can find the Fraunhofer ILT at the joint Fraunhofer booth SC01 in Hall 7.

K is the world’s largest trade fair for the plastics and rubber industry. As in previous years, the organizers are expecting 3,000 exhibitors and more than...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Experts from industry and academia discuss the future mobile telecommunications standard 5G

23.09.2016 | Event News

ICPE in Graz for the seventh time

20.09.2016 | Event News

Using mathematical models to understand our brain

16.09.2016 | Event News

 
Latest News

Stronger turbine blades with molybdenum silicides

26.09.2016 | Materials Sciences

Scientists Find Twisting 3-D Raceway for Electrons in Nanoscale Crystal Slices

26.09.2016 | Materials Sciences

Lowering the Heat Makes New Materials Possible While Saving Energy

26.09.2016 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>