Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tumor size predicts survival in most common type of lung cancer

11.11.2003


Tumor size can predict the survival of a patient with the most common type of lung cancer, according to physician-scientists at NewYork Weill Cornell Medical Center. The study, which is the lead paper in this month’s Chest, emphasizes the need for further substaging in lung cancer and suggests the importance of early detection by CT scans.



The study evaluates the relationship between tumor size and five-year survival in patients with stage IA non-small cell lung cancer (NSCLC). Researchers reviewed the history of 244 patients treated at NewYork-Presbyterian Hospital/Weill Cornell Medical Center who underwent surgical resection for lung tumors between 1991 and 2001. Overall survival rates and survival rates specific to lung cancer were analyzed and compared to tumor size. The overall five-year survival rate for all patients was 71.1 percent, and the five-year disease-specific survival was 74.9 percent. Significantly, tumor size was an important predictor of long-term survival: disease-specific survival was 81.4 percent for patients with tumors less than or equal to 2.0 cm and only 63.4 percent for patients with tumors greater than 2.0 cm.

"These findings should encourage CT screening, which can detect tumors smaller than one centimeter," says Dr. Nasser K. Altorki, the study’s principal investigator, Professor of Cardiothoracic Surgery at Weill Cornell Medical College, and Director of the Division of Thoracic Surgery at NewYork-Presbyterian Hospital/Weill Cornell Medical Center. "The message is clear: early detection of tumors means better odds of survival."


Further, because the study identifies differences in survival within stage IA, the authors call for further substaging. "We found that a tumor size difference of even one centimeter can impact survival, leading us to believe that further substaging of stage IA lung cancer is necessary to ensure patients in this stage are receiving the most effective treatment," says Dr. Altorki.

Previous studies have noted a sharp difference in survival between patients with nonmetastasized tumors less than 3 cm (stage IA) and tumors more than 3 cm in size (stage IB), but little information has been available on whether size remains an important determinant of survival in tumors less than 3 cm. The study’s authors plan continued investigation of the relationship between NSCLC tumor size and survival. "Further investigation may identify a tumor-size threshold below which there is minimal or reduced risk of tumor metastases," says Dr. Altorki.

In the United States, lung cancer causes more deaths in both men and women than the next three most common cancers combined (colon cancer, 48,100 deaths; breast cancer, 40,000 deaths; and prostate, 30,200 deaths). It has been estimated that 169,400 individuals in the United States received a diagnosis of lung cancer in 2002 (90,200 men and 79,200 women), and 154,900 individuals died from the disease during that year.

The paper is co-authored by Dr. Jeffrey L. Port, Assistant Professor of Cardiothoracic Surgery at Weill Cornell Medical College and Assistant Attending Cardiothoracic Surgeon at NewYork-Presbyterian Hospital/Weill Cornell Medical Center; Dr. Michael Kent, Weill Cornell graduate staff; Dr. Robert Korst, Assistant Professor of Cardiothoracic Surgery at Weill Cornell Medical College and Assistant Attending Cardiothoracic Surgeon at NewYork Weill Cornell; Dr. Daniel Libby, Clinical Professor of Medicine at Weill Cornell Medical College and Attending Physician at NewYork Weill Cornell; and Dr. Mark Pasmantier, Clinical Professor of Medicine at Weill Cornell Medical College and Attending Physician at NewYork Weill Cornell.

The NewYork Weill Cornell Medical Center, located in Manhattan on the Upper East Side at York Avenue and 68th Street, comprises NewYork-Presbyterian Hospital and Weill Cornell Medical College.


Office of Public Affairs NewYork-Presbyterian Hospital/Weill Cornell Medical Center 525 East 68th Street, Box 144 New York, NY 10021

Jonathan Weil | Cornell News
Further information:
http://www.news.cornell.edu/releases/Nov03/tumorsize.html

More articles from Health and Medicine:

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

nachricht Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Space-like gravity weakens biochemical signals in muscle formation

23.05.2018 | Life Sciences

NIST puts the optical microscope under the microscope to achieve atomic accuracy

23.05.2018 | Physics and Astronomy

Magnesium magnificent for plasmonic applications

23.05.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>