Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tumor size predicts survival in most common type of lung cancer

11.11.2003


Tumor size can predict the survival of a patient with the most common type of lung cancer, according to physician-scientists at NewYork Weill Cornell Medical Center. The study, which is the lead paper in this month’s Chest, emphasizes the need for further substaging in lung cancer and suggests the importance of early detection by CT scans.



The study evaluates the relationship between tumor size and five-year survival in patients with stage IA non-small cell lung cancer (NSCLC). Researchers reviewed the history of 244 patients treated at NewYork-Presbyterian Hospital/Weill Cornell Medical Center who underwent surgical resection for lung tumors between 1991 and 2001. Overall survival rates and survival rates specific to lung cancer were analyzed and compared to tumor size. The overall five-year survival rate for all patients was 71.1 percent, and the five-year disease-specific survival was 74.9 percent. Significantly, tumor size was an important predictor of long-term survival: disease-specific survival was 81.4 percent for patients with tumors less than or equal to 2.0 cm and only 63.4 percent for patients with tumors greater than 2.0 cm.

"These findings should encourage CT screening, which can detect tumors smaller than one centimeter," says Dr. Nasser K. Altorki, the study’s principal investigator, Professor of Cardiothoracic Surgery at Weill Cornell Medical College, and Director of the Division of Thoracic Surgery at NewYork-Presbyterian Hospital/Weill Cornell Medical Center. "The message is clear: early detection of tumors means better odds of survival."


Further, because the study identifies differences in survival within stage IA, the authors call for further substaging. "We found that a tumor size difference of even one centimeter can impact survival, leading us to believe that further substaging of stage IA lung cancer is necessary to ensure patients in this stage are receiving the most effective treatment," says Dr. Altorki.

Previous studies have noted a sharp difference in survival between patients with nonmetastasized tumors less than 3 cm (stage IA) and tumors more than 3 cm in size (stage IB), but little information has been available on whether size remains an important determinant of survival in tumors less than 3 cm. The study’s authors plan continued investigation of the relationship between NSCLC tumor size and survival. "Further investigation may identify a tumor-size threshold below which there is minimal or reduced risk of tumor metastases," says Dr. Altorki.

In the United States, lung cancer causes more deaths in both men and women than the next three most common cancers combined (colon cancer, 48,100 deaths; breast cancer, 40,000 deaths; and prostate, 30,200 deaths). It has been estimated that 169,400 individuals in the United States received a diagnosis of lung cancer in 2002 (90,200 men and 79,200 women), and 154,900 individuals died from the disease during that year.

The paper is co-authored by Dr. Jeffrey L. Port, Assistant Professor of Cardiothoracic Surgery at Weill Cornell Medical College and Assistant Attending Cardiothoracic Surgeon at NewYork-Presbyterian Hospital/Weill Cornell Medical Center; Dr. Michael Kent, Weill Cornell graduate staff; Dr. Robert Korst, Assistant Professor of Cardiothoracic Surgery at Weill Cornell Medical College and Assistant Attending Cardiothoracic Surgeon at NewYork Weill Cornell; Dr. Daniel Libby, Clinical Professor of Medicine at Weill Cornell Medical College and Attending Physician at NewYork Weill Cornell; and Dr. Mark Pasmantier, Clinical Professor of Medicine at Weill Cornell Medical College and Attending Physician at NewYork Weill Cornell.

The NewYork Weill Cornell Medical Center, located in Manhattan on the Upper East Side at York Avenue and 68th Street, comprises NewYork-Presbyterian Hospital and Weill Cornell Medical College.


Office of Public Affairs NewYork-Presbyterian Hospital/Weill Cornell Medical Center 525 East 68th Street, Box 144 New York, NY 10021

Jonathan Weil | Cornell News
Further information:
http://www.news.cornell.edu/releases/Nov03/tumorsize.html

More articles from Health and Medicine:

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

nachricht The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>