Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tumor size predicts survival in most common type of lung cancer

11.11.2003


Tumor size can predict the survival of a patient with the most common type of lung cancer, according to physician-scientists at NewYork Weill Cornell Medical Center. The study, which is the lead paper in this month’s Chest, emphasizes the need for further substaging in lung cancer and suggests the importance of early detection by CT scans.



The study evaluates the relationship between tumor size and five-year survival in patients with stage IA non-small cell lung cancer (NSCLC). Researchers reviewed the history of 244 patients treated at NewYork-Presbyterian Hospital/Weill Cornell Medical Center who underwent surgical resection for lung tumors between 1991 and 2001. Overall survival rates and survival rates specific to lung cancer were analyzed and compared to tumor size. The overall five-year survival rate for all patients was 71.1 percent, and the five-year disease-specific survival was 74.9 percent. Significantly, tumor size was an important predictor of long-term survival: disease-specific survival was 81.4 percent for patients with tumors less than or equal to 2.0 cm and only 63.4 percent for patients with tumors greater than 2.0 cm.

"These findings should encourage CT screening, which can detect tumors smaller than one centimeter," says Dr. Nasser K. Altorki, the study’s principal investigator, Professor of Cardiothoracic Surgery at Weill Cornell Medical College, and Director of the Division of Thoracic Surgery at NewYork-Presbyterian Hospital/Weill Cornell Medical Center. "The message is clear: early detection of tumors means better odds of survival."


Further, because the study identifies differences in survival within stage IA, the authors call for further substaging. "We found that a tumor size difference of even one centimeter can impact survival, leading us to believe that further substaging of stage IA lung cancer is necessary to ensure patients in this stage are receiving the most effective treatment," says Dr. Altorki.

Previous studies have noted a sharp difference in survival between patients with nonmetastasized tumors less than 3 cm (stage IA) and tumors more than 3 cm in size (stage IB), but little information has been available on whether size remains an important determinant of survival in tumors less than 3 cm. The study’s authors plan continued investigation of the relationship between NSCLC tumor size and survival. "Further investigation may identify a tumor-size threshold below which there is minimal or reduced risk of tumor metastases," says Dr. Altorki.

In the United States, lung cancer causes more deaths in both men and women than the next three most common cancers combined (colon cancer, 48,100 deaths; breast cancer, 40,000 deaths; and prostate, 30,200 deaths). It has been estimated that 169,400 individuals in the United States received a diagnosis of lung cancer in 2002 (90,200 men and 79,200 women), and 154,900 individuals died from the disease during that year.

The paper is co-authored by Dr. Jeffrey L. Port, Assistant Professor of Cardiothoracic Surgery at Weill Cornell Medical College and Assistant Attending Cardiothoracic Surgeon at NewYork-Presbyterian Hospital/Weill Cornell Medical Center; Dr. Michael Kent, Weill Cornell graduate staff; Dr. Robert Korst, Assistant Professor of Cardiothoracic Surgery at Weill Cornell Medical College and Assistant Attending Cardiothoracic Surgeon at NewYork Weill Cornell; Dr. Daniel Libby, Clinical Professor of Medicine at Weill Cornell Medical College and Attending Physician at NewYork Weill Cornell; and Dr. Mark Pasmantier, Clinical Professor of Medicine at Weill Cornell Medical College and Attending Physician at NewYork Weill Cornell.

The NewYork Weill Cornell Medical Center, located in Manhattan on the Upper East Side at York Avenue and 68th Street, comprises NewYork-Presbyterian Hospital and Weill Cornell Medical College.


Office of Public Affairs NewYork-Presbyterian Hospital/Weill Cornell Medical Center 525 East 68th Street, Box 144 New York, NY 10021

Jonathan Weil | Cornell News
Further information:
http://www.news.cornell.edu/releases/Nov03/tumorsize.html

More articles from Health and Medicine:

nachricht New study points the way to therapy for rare cancer that targets the young
22.11.2017 | Rockefeller University

nachricht Penn study identifies new malaria parasites in wild bonobos
21.11.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Corporate coworking as a driver of innovation

22.11.2017 | Business and Finance

PPPL scientists deliver new high-resolution diagnostic to national laser facility

22.11.2017 | Physics and Astronomy

Quantum optics allows us to abandon expensive lasers in spectroscopy

22.11.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>