Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Inflammation kills new brain cells

10.11.2003


A research team at Lund University in Sweden attracted international attention a year ago by showing that new nerve cells can be generated in the brain after a stroke. However, most of these new nerve cells die rather soon. The same research team has now been able to show that an inflammation can lie behind the death of these new nerve cells, which instills hope for improved treatments for various brain disorders.



The new growth of nerve cells following epilepsy or stroke has been shown in animal studies to take place in two parts of the brain: the striatum and the hippocampus (a part that is of special importance for the memory, learning, and moods). These same areas are involved in the new formation of nerve cells in the human brain as well.

But many of the newly generated nerve cells perish rather quickly. The Lund research team, including Professor Olle Lindvall, Associate Professor Zaal Kokaia, and Doctor of Medicine Christine Ekdahl Clementson, have now been able to explain in an article in Proceedings of the National Academy of Sciences in the US that this is largely caused by an inflammatory process. They have demonstrated this in two ways: both by inducing an inflammation, which led to the death of nerve cells, and in reverse experiments by administering anti-inflammatory medicine, which reduced the number of nerve cells that died.


Inflammation of the brain occurs not only in connection with epilepsy and stroke but also in Alzheimer’s and other forms of dementia. In the future the new discoveries might lead to improved treatment of these diseases. But a great deal of research remains to be done.

“First we need to find out what function the newly formed nerve cells have. We know that the cells are of the same sort as those that are lost in a stroke, for example, but we don’t know whether the cells become fully functional to the point where they could help repair damage,” says Associate Professor Zaal Kokaia.

“We also want to learn more about the inflammatory process, which is extremely complicated. It triggers a number of different substances, and we would like to know which of them are causing cell death.”

The Lund scientists are going to pursue both of these leads in their further research.

This also has bearing on research into stem cells, which the Lund team is also working with, since transplanted cells probably also risk dying from inflammations that arise in the brain.

Ingela Björck | alfa
Further information:
http://v

More articles from Health and Medicine:

nachricht Hot cars can hit deadly temperatures in as little as one hour
24.05.2018 | Arizona State University

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>