Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Jefferson Scientists Define New Cell Type That May Lead to Clues About Kaposi’s Sarcoma


For years, the origin of Kaposi’s sarcoma (KS), a rare cancer that sometimes afflicts those infected with HIV, the AIDS virus, has puzzled researchers. Now, pathologists at Jefferson Medical College may be uncovering some of its secrets.

George Murphy, M.D., professor of pathology at Jefferson Medical College of Thomas Jefferson University in Philadelphia, and Masatoshi Deguchi, M.D., visiting scientist from Tohuku University in Sendai, Japan, have created a mouse model that resembles an early form of KS. To accomplish this, they have grown and characterized a line of mouse skin cells in the laboratory that they believe are analogous to the cells that go awry early on in human KS.

The type of cell, termed a “dermal dendrocyte,” increases dramatically in number in tumors in early human KS, he says. When Dr. Murphy and his co-workers injected the dermal dendrocytes directly into normal mouse skin, the injected areas developed features similar to human KS.

The findings may lead to insights into the origins of other diseases, such as scleroderma, abnormal wound healing and a chronic form of graft-versus-host-disease involved in bone marrow transplantation.

Dr. Murphy and his group report their findings November 1 in the American Journal of Pathology.

According to Dr. Murphy, KS usually begins as one of many bruise-like areas on the skin that develops over time into tumors. KS may also affect internal organs, particularly in AIDS, and may be fatal.

Dermal dendrocytes – which have been known to exist only since 1985 – may play roles in wound healing or in the immune system. There is evidence for both.

“It’s interesting that in AIDS, it is occurring in the setting of immune disease, and involves an immune cell proliferating abnormally,” he says. What’s more, “KS can occur in areas of trauma,” he says, “and a wound healing cell might be proliferating abnormally” in such conditions.

When the dermal dendrocyte was first discovered in 1985, scientists found that the cell type contained a blood clotting factor. One explanation for this might be that the cell secretes the clotting factor to help form initial blood clots after injury and begin the healing process.

“The problem of understanding the biology and pathogenesis of KS and the dermal dendrocytes is that we’ve never had a purified cell line to study until now,” Dr. Murphy. “Now we have a cell line that is purified and expresses a blood clotting factor.”

“We now have an important tool to study KS not only experimentally because we have the early cell that we think contributes to the pathogenesis of the disease,” he says. “We also have the cell that we could never study in a purified manner before that might have a lot to do with abnormal wound healing and diseases such as scleroderma. It opens up a new area of inquiry.”

“It’s a potential mouse model for KS,” Dr. Murphy says. “What are missing are the other co-factors that would lead the evolution of the early lesion to the late lesion that kills patients.” These could include immunodeficiency, HIV or other viruses such as herpesvirus-8, which has been found in KS.

“Now, the mouse model that we have established can be studied by introducing these other factors and see if they can induce these early lesions to behave like the natural history of the human lesion.”

Steven Benowitz | TJUH
Further information:

More articles from Health and Medicine:

nachricht Inflammation Triggers Unsustainable Immune Response to Chronic Viral Infection
24.10.2016 | Universität Basel

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

The nanostructured cloak of invisibility

25.10.2016 | Life Sciences

Oasis of life in the ice-covered central Arctic

24.10.2016 | Earth Sciences

‘Farming’ bacteria to boost growth in the oceans

24.10.2016 | Life Sciences

More VideoLinks >>>