For years, the origin of Kaposi’s sarcoma (KS), a rare cancer that sometimes afflicts those infected with HIV, the AIDS virus, has puzzled researchers. Now, pathologists at Jefferson Medical College may be uncovering some of its secrets.
George Murphy, M.D., professor of pathology at Jefferson Medical College of Thomas Jefferson University in Philadelphia, and Masatoshi Deguchi, M.D., visiting scientist from Tohuku University in Sendai, Japan, have created a mouse model that resembles an early form of KS. To accomplish this, they have grown and characterized a line of mouse skin cells in the laboratory that they believe are analogous to the cells that go awry early on in human KS.
The type of cell, termed a “dermal dendrocyte,” increases dramatically in number in tumors in early human KS, he says. When Dr. Murphy and his co-workers injected the dermal dendrocytes directly into normal mouse skin, the injected areas developed features similar to human KS.
Steven Benowitz | TJUH
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The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.
The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
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An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
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Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
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