Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Jefferson Scientists Define New Cell Type That May Lead to Clues About Kaposi’s Sarcoma

10.11.2003


For years, the origin of Kaposi’s sarcoma (KS), a rare cancer that sometimes afflicts those infected with HIV, the AIDS virus, has puzzled researchers. Now, pathologists at Jefferson Medical College may be uncovering some of its secrets.



George Murphy, M.D., professor of pathology at Jefferson Medical College of Thomas Jefferson University in Philadelphia, and Masatoshi Deguchi, M.D., visiting scientist from Tohuku University in Sendai, Japan, have created a mouse model that resembles an early form of KS. To accomplish this, they have grown and characterized a line of mouse skin cells in the laboratory that they believe are analogous to the cells that go awry early on in human KS.

The type of cell, termed a “dermal dendrocyte,” increases dramatically in number in tumors in early human KS, he says. When Dr. Murphy and his co-workers injected the dermal dendrocytes directly into normal mouse skin, the injected areas developed features similar to human KS.


The findings may lead to insights into the origins of other diseases, such as scleroderma, abnormal wound healing and a chronic form of graft-versus-host-disease involved in bone marrow transplantation.

Dr. Murphy and his group report their findings November 1 in the American Journal of Pathology.

According to Dr. Murphy, KS usually begins as one of many bruise-like areas on the skin that develops over time into tumors. KS may also affect internal organs, particularly in AIDS, and may be fatal.

Dermal dendrocytes – which have been known to exist only since 1985 – may play roles in wound healing or in the immune system. There is evidence for both.

“It’s interesting that in AIDS, it is occurring in the setting of immune disease, and involves an immune cell proliferating abnormally,” he says. What’s more, “KS can occur in areas of trauma,” he says, “and a wound healing cell might be proliferating abnormally” in such conditions.

When the dermal dendrocyte was first discovered in 1985, scientists found that the cell type contained a blood clotting factor. One explanation for this might be that the cell secretes the clotting factor to help form initial blood clots after injury and begin the healing process.

“The problem of understanding the biology and pathogenesis of KS and the dermal dendrocytes is that we’ve never had a purified cell line to study until now,” Dr. Murphy. “Now we have a cell line that is purified and expresses a blood clotting factor.”

“We now have an important tool to study KS not only experimentally because we have the early cell that we think contributes to the pathogenesis of the disease,” he says. “We also have the cell that we could never study in a purified manner before that might have a lot to do with abnormal wound healing and diseases such as scleroderma. It opens up a new area of inquiry.”

“It’s a potential mouse model for KS,” Dr. Murphy says. “What are missing are the other co-factors that would lead the evolution of the early lesion to the late lesion that kills patients.” These could include immunodeficiency, HIV or other viruses such as herpesvirus-8, which has been found in KS.

“Now, the mouse model that we have established can be studied by introducing these other factors and see if they can induce these early lesions to behave like the natural history of the human lesion.”

Steven Benowitz | TJUH
Further information:
http://www.jeffersonhospital.org/news/e3front.dll?durki=17237

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Strathclyde-led research develops world's highest gain high-power laser amplifier

The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.

The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

New insights into the ancestors of all complex life

29.05.2017 | Earth Sciences

New photocatalyst speeds up the conversion of carbon dioxide into chemical resources

29.05.2017 | Life Sciences

NASA's SDO sees partial eclipse in space

29.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>