Researchers led by Jason Jaworski, PhD, and Michael Kuhar, PhD, both at the Yerkes National Primate Research Center at Emory University, have shown that CART peptide, a chemical that occurs naturally in both the rodent and human brain, reduces some effects of cocaine when additional amounts are administered to the region of the brain that is associated with reward and addiction. These findings, which appear online in the Journal of Pharmacology and Experimental Therapeutics and which will be presented on November 8 at the Society for Neuroscience meeting in New Orleans, suggest CART peptide receptors in the brain could be targets for developing medications to treat cocaine abuse.
For their study, Dr. Jaworski, a post-doctoral fellow, and Dr. Kuhar, chief of the Neuroscience Division at Yerkes and a Georgia Research Alliance Eminent Scholar, infused CART peptide into the nucleus accumbens (NA) of rodents to determine how it affects the increase of body movement, or locomotor activity, that is widely seen as one effect of psychostimulant drugs. The researchers observed that the cocaine-induced movement was reduced after the rodents received CART peptide. "This is the first study to demonstrate CART peptides in the nucleus accumbens hinder the effects of cocaine," said Dr. Jaworski. "Our findings open a door to develop potential treatment options for cocaine addiction."
When infused into other areas of the "pleasure pathway," the part of the brain in both rodents and humans that is activated when cocaine is administered, CART peptide has been shown to produce minimal psychostimulant-like effects. "Past studies have shown CART peptide is slightly cocaine-like in other areas of the brain, but nevertheless inhibits further stimulation from the drug," said Dr. Kuhar. "While additional research will be necessary, we have demonstrated the importance of CART peptide in combating or slowing down some of the effects of cocaine."
Kelly Duncan | EurekAlert!
NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases
Researchers identify key step in viral replication
13.03.2018 | University of Pittsburgh Schools of the Health Sciences
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.
When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...
19.03.2018 | Event News
16.03.2018 | Event News
13.03.2018 | Event News
19.03.2018 | Physics and Astronomy
19.03.2018 | Materials Sciences
19.03.2018 | Event News