Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Direct link found between chronic inflammation, colon cancer

05.11.2003


Investigators in the A.B. Hancock Jr. Memorial Research Center at Vanderbilt have identified a type of DNA damage caused by chronic inflammation as a potential risk factor for colorectal cancer.



The findings, published this week in the early online edition of the website of the Proceedings of the National Academy of Science (www.pnas.org), shed more light on the role that inflammation might play in cancer and suggests that measurement of this type of DNA damage might be useful in assessment and management of a patient’s colorectal cancer risk.

"A number of studies have implicated chronic inflammation in the development of cancers, but the specific way that occurs is not clear," said Dr. Lawrence J. Marnett, Ph.D., director of the Hancock Research Center and the Vanderbilt Institute of Chemical Biology.


"These studies suggest a direct link between oxidative stress, like that seen in chronic inflammation, and genetic mutations that cause human disease."

The work reported in PNAS builds on years of research at Vanderbilt into how overproduction of the inflammation-causing enzyme cyclooxygenase-2 (COX-2) may contribute to cancer – and conversely, how aspirin-like drugs that block COX-2 might help treat or prevent cancer.

"When the body experiences oxidative stress, molecules called free radicals are produced, and these free radicals can damage cells – the cell membrane and the DNA," Marnett said.

The researchers examined a type of DNA damage caused by malondialdehye (MDA), a product of COX-2. The question they wanted to answer was whether the DNA damage would stop with the damaged cell or whether it would cause genetic abnormalities, or mutations, which would be replicated in future cell lines.

They built a DNA molecule that incorporated the MDA-caused damage and inserted that into mammalian kidney cells. After the cells divided, the DNA was recovered from the new cells and examined for mutations.

The researchers found that, indeed, the DNA damage had resulted in a specific type of genetic change called a "frameshift mutation." These mutations delete a small portion of DNA, effectively throwing off the "reading frame" through which the genes’ instructions are interpreted and resulting in a protein that doesn’t do what it is supposed to do.

Interestingly, these types of mutations are common in an inherited form of colon cancer, Hereditary Non-Polyposis Colon Cancer (HPNCC). This work suggests that these mutations, caused by inflammation and other oxidative stress, might also contribute to colorectal cancer.

Co-investigators in the research include Laurie A. VanderVeen, Muhammed F. Hashim and Yu Shyr, representing the Hancock Research Center, the VICB, the Vanderbilt-Ingram Cancer Center, the Vanderbilt Center for Molecular Toxicology and the Vanderbilt School of Medicine departments of Biochemistry and Preventive Medicine.

Cynthia Floyd Manley | EurekAlert!
Further information:
http://www.mc.vanderbilt.edu/reporter

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>