Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cervical cancer screening

04.11.2003


No proven benefit of detection of human papillomavirus alone compared with the conventional Pap smear

Under the aegis of the French Society of Clinical Cytology, physicians at the Institut Curie have evaluated the relevance of the papillomavirus detection test, Hybrid Capture‚ II, in screening for cervical cancer, the second most common cancer in women worldwide. They have shown that this test cannot replace cytological analysis of the cervical smear.
For the first time a learned society, the French Society of Clinical Cytology, has organized a multicenter, national study in general practice. Cervical cancer screening is one of 70 priority measures in France’s Cancer Plan, and an important goal is to establish a test that combines reliability, feasibility and affordability. This work was published in the October 2003 issue of the American Journal of Clinical Pathology.


Cervical cancer is the second most common cancer in women, with 465 000 new cases and 200 000 deaths worldwide every year. In France, 3 387 new cases and 1 000 deaths were recorded in 2000. Cervical cancer affects women in all age ranges, from 25 years upwards.

Cervical cancer screening: a national priority

Early detection of cervical cancer through intensified screening is one of the 70 measures of the Cancer Plan launched in France by the President of the Republic. Screening is based on the cervical smear test. In this simple and painless test, cells are collected from the surface of the cervix and are examined under the microscope for any anomaly suggestive of lesions that are precancerous or cancerous. It should be performed every three years.

The Cancer Plan is intended to broaden availability of the smear test (family planning, occupational medicine...) to women who do not have a gynecologist, so as to intensify information actions and facilitate testing for papillomavirus infection.
In France, generalization of the smear test has already led to a reduction in the incidence of cervical cancer: the number of cases decreased from 5 992 in 1975 to 3 387 in 2000, i.e. a 46 % decrease in 25 years.

This incidence though is still high, possibly due to the fact that the female population is not fully covered and also because some women develop cervical cancer despite regular smear tests, which clearly have shortcomings (false-negatives, absence of abnormal cells in the area of the smear…). Screening should be improved by the implementation of more sensitive tests.

Comparison of detection of HPV and cytologic analysis

Close to 90% of cervical cancers develop from pre-invasive lesions due to a human papillomavirus (HPV). The efficiency of screening could be improved by the inclusion of testing for HPV.

Under the aegis of the French Society of Clinical Cytology, physicians of the Institut Curie, coordinated by Dr Béatrix Cochand-Priollet (1) have evaluated the efficiency and relevance of the Hybrid Capture‚ II papillomavirus DNA test (HC-II) (2). This test performed on the cervical smear detects papillomavirus DNA and distinguishes high-risk from low-risk HPVs.

By comparing cytologic analyses and the HC-II test in 1 785 patients, the Institut Curie physicians have shown that the HC-II test performed alone is less sensitive than cytologic analysis of a cervical smear.

In conclusion, comparative analysis of the sensitivity and specificity of the HC-II technique and of the conventional Pap smear reveals no advantage of HPV detection alone in the framework of cervical cancer screening.

It is therefore unlikely that the HC-II test will replace cytologic analysis, but it could in certain cases be complementary. Further studies are needed to define the role of the HC-II test in cervical cancer screening and follow-up.


Note

(1) Dr Béatrix Cochand-Priollet works in the Pathological Anatomy and Cytology Department of the Hôpital Lariboisière.
(2) This test is manufactured by Digene“ (Gaithersburg, USA).

Catherine Goupillon | Institut Curie

More articles from Health and Medicine:

nachricht Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital

nachricht New Hope for Cancer Therapies: Targeted Monitoring may help Improve Tumor Treatment
01.12.2017 | Berliner Institut für Gesundheitsforschung / Berlin Institute of Health (BIH)

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

Im Focus: Virtual Reality for Bacteria

An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications

Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...

Im Focus: A space-time sensor for light-matter interactions

Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.

The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Midwife and signpost for photons

11.12.2017 | Physics and Astronomy

How do megacities impact coastal seas? Searching for evidence in Chinese marginal seas

11.12.2017 | Earth Sciences

PhoxTroT: Optical Interconnect Technologies Revolutionized Data Centers and HPC Systems

11.12.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>