Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Breast cancer can be reversed in laboratory mice, scientists report

04.11.2003


Findings provide new molecular drug targets, validate transgenic mouse models



Breast cancer researchers have demonstrated for the first time that it is possible to block genetic switches in mice that turn cancer on and off — thus preventing and even reversing breast cancer in the animals. The findings, reported Sunday morning at the 24th Congress of the International Association for Breast Cancer Research, suggest potential new molecular targets for drugs to prevent and potentially eradicate breast cancer in humans.

“It’s enormously gratifying,” said conference director Robert Cardiff, professor of pathology at UC Davis School of Medicine and Medical Center and an author of the research. “Our findings suggest paths forward that may help us alter the biological path of breast cancer and more successfully treat — and even potentially prevent — this cancer in humans.”


In new research reported by a team of scientists from Canada, Switzerland and UC Davis, investigators demonstrated that removing a single gene known as beta-1 integrin prevented or halted breast cancer growth in laboratory mice. Beta-1 integrin is a principal regulator of normal breast tissue growth and survival, but if the gene malfunctions, it can directly initiate breast tumors. The new work demonstrates that knocking out the beta-1 integrin gene prevents cancer-prone mice from developing breast tumors, and halts further tumor growth in mice that have already developed breast cancer.

“This study shows that it is absolutely essential to have the beta-1 integrin gene present in order for mammary gland tumors to develop. We now have a good target for biological drug development, and the challenge is to develop an agent that can block its activity,” said William J. Muller, professor of biochemistry at McGill University in Montreal and a lead investigator of the study.

In a related presentation, researchers from the University of Pennsylvania reported on a series of experiments using a novel mouse model of human breast cancer, one that enables scientists to turn oncogenes — genes that can cause cancer — on or off at will. A triggering agent, in this case the antibiotic doxycycline, throws the switch on or off. Scientists used the approach to test four oncogenes: c-myc, Neu, Wnt1, and v-Ha-Ras. When any one of the oncogenes was turned on, the transgenic mice developed extremely aggressive mammary tumors; in many cases, the tumors metastasized to the lungs. When the gene was turned off, many of the breast tumors — including many of the most aggressive and advanced cancers — regressed to the point that they no longer could be detected by physical examination, magnetic resonance imaging (MRI) or positron emission tomography (PET) scans.

“We’re extremely encouraged that we have been able to demonstrate in laboratory animals that we can make mammary cancers essentially disappear by reversing just one mutation,” said Lewis A. Chodosh, associate professor at the Abramson Family Cancer Research Center at the University of Pennsylvania and lead author of the study.
“This suggests that, with appropriate therapies that target the genes used in this study, we might be able to cause tumors to regress and improve substantially, even those that are quite advanced.”

However, even though many of the tumors in the transgenic mice went into complete remission, a substantial number of the cancers spontaneously recurred over periods of up to a year, Chodosh reported.

This finding is important since it replicates the natural history of human breast cancer — many women, after apparently successful treatment, harbor residual tumor cells that eventually give rise to tumor recurrences that ultimately may result in death. Some of these residual cells can remain for decades. No previous laboratory mouse model has successfully replicated this feature of human breast cancer cells.

“The next critical step is to figure out the mechanisms that some tumors use to escape these treatments,” Chodosh said. “We believe these mouse models will help us to do exactly that.”

Founded in the mid 1950s, the International Association for Breast Cancer Research is an international community of scientists focused on the important issues in modern breast cancer research. The 24th IABCR Congress, focused on preclinical research using mouse models of human breast cancer, is sponsored by UC Davis Cancer Center, the Office of Women’s Health of the U.S. Department of Health and Human Services, the California Breast Cancer Research Program, and the National Cancer Institute’s Mouse Models of Human Cancers Consortium and Specialized Programs of Research Excellence.

Claudia Morain | UC Davis Health System
Further information:
http://cme.ucdmc.ucdavis.edu/iabcr.htm
http://news.ucdmc.ucdavis.edu
http://cme.ucdmc.ucdavis.edu/Confrnce/IABCR/reversed.html

More articles from Health and Medicine:

nachricht FAU researchers demonstrate that an oxygen sensor in the body reduces inflammation
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

nachricht 'Icebreaker' protein opens genome for t cell development, Penn researchers find
21.02.2018 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

The RWI/ISL-Container Throughput Index started off well in 2018

22.02.2018 | Business and Finance

FAU researchers demonstrate that an oxygen sensor in the body reduces inflammation

22.02.2018 | Health and Medicine

Histology in 3D: new staining method enables Nano-CT imaging of tissue samples

22.02.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>