Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

OHSU doctors use ’putty’ to prevent hemorrhagic stroke

31.10.2003


Oregon patients are first on West Coast to take part in clinical trial



Two Oregon Health & Science University patients are the first on the West Coast to receive a new stroke prevention treatment that uses a spongy, polymer compound to seal a brain aneurysm.

The patients, Joyce Turner, 68, of Kings Valley and Rob Pardee, 48, of Talent, underwent back-to-back procedures Oct. 23 at OHSU Hospital to repair aneurysms – weakened areas of an artery wall that balloon out and fill with fluid – that were at risk of rupturing. Both were able to go home the next day.


Stanley L. Barnwell, M.D., Ph.D., associate professor of neurological surgery in the OHSU School of Medicine and the Dotter Interventional Institute, performed the procedure on Turner and Pardee as part of a 120-patient clinical trial for the new Onyx Liquid Embolic System, developed by Irvine, Calif.-based Micro Therapeutics Inc. (MTI).

The Oregon Stroke Center at OHSU is one of 10 sites nationwide participating in the clinical trial for Onyx. Wayne M. Clark, M.D., professor of neurology in OHSU’s School of Medicine and the Dotter Interventional Institute, as well as the Oregon Stroke Center’s director, is the principal investigator of a study that will compare the Onyx procedure with other aneurysm treatments, such as coiling.

Using a catheter fed from the groin to a carotid artery in the brain, Barnwell locates the aneurysm and injects the Onyx liquid into the sac. When the liquid comes in contact with blood or body fluids, according to MTI, a solvent rapidly diffuses from the liquid, transforming it into a spongy, polymer mass that displaces the blood in the sac and seals off the defect. The solvent, dimethyl sulfoxide, or DMSO, is derived from lignin, a compound found in woody plants.

"It’s a little bit like placing putty in a hole in the wall," Barnwell said. "It if stops an aneurysm from growing back, it’ll be very useful."

Indeed, Turner and Pardee say, before-and-after images of their aneurysms – Turner’s was in her right internal carotid artery, behind her eye under the frontal lobe, and Pardee’s was in his left internal carotid artery, also behind the eye – appear to show the malformations are gone.

"My before-and-after pictures are incredible," Pardee said. "You can’t tell it’s there. I saw that and I thought, ’Yeah, OK, this is good!’"

Turner had a similar response: "I was amazed it made the aneurysm much smaller," she said of the procedure. "It did seem like it drew it down. Now there’s just a hump instead of a balloon. It’s good stuff."

Had the aneurysms burst, the likely result would have been a subarachnoid hemorrhage, a type of stroke in which blood escapes into the space between the brain and the skull, cutting off its flow to the brain.

A common treatment for an aneurysm is coiling, in which a tiny platinum coil is inserted into the sac through a catheter and deployed, restricting blood flow into the malformation. But the coil can fall out of the sac and back into the artery, and sometimes blood flow into the sac isn’t fully restricted.

"Coils can stick out, and sometimes you can’t get the coil where you need it," Clark said. And there is a 20 percent aneurysm recurrence rate among coiling patients.

But in the Onyx procedure, an angioplasty balloon can be used to hold the liquid inside the sac while it’s being injected, preventing it from falling out before it solidifies.

"The balloon keeps it out of the artery and once it hardens, the balloon is deflated and it stays there," Barnwell said.

The other solution for an aneurysm is surgical clipping, in which a tiny metal clip is placed on the neck of the aneurysm to pinch off blood flow into the sac. But the clip stays in the patient forever, and the procedure requires brain surgery and months of recovery.

The Onyx procedure takes the same amount of time as coiling – about an hour – although it’s more complex. "But once we get some experience with it, it’ll become routine," Barnwell said.

Clark, who says the Onyx material looks and acts like "squishy rubber cement," believes the new procedure will have significant advantages over invasive brain surgery and, perhaps, coiling. "Whether it’s better than coiling, that’s what the study is evaluating," he said. "It certainly looks very promising."

In the meantime, Turner and Pardee look forward to speedy recoveries.

"From being active and doing everything to being down and not doing anything, I was ready for any cure," said Turner, who hopes the Onyx procedure helps alleviate the headaches, dizziness and fatigue she’s been experiencing the last several months. "I just want my last few years to be quality time."

Said Pardee, who’s also suffered from headaches: "Like the doctor says, ’Maybe it’ll get rid of the headaches, maybe it won’t. But (the aneurysm) will kill you someday.’ Normally, you don’t get a chance to take care of things like that ahead of time. It’s phenomenal what they can do."

Jonathan Modie | EurekAlert!
Further information:
http://www.ohsu.edu/

More articles from Health and Medicine:

nachricht New study points the way to therapy for rare cancer that targets the young
22.11.2017 | Rockefeller University

nachricht Penn study identifies new malaria parasites in wild bonobos
21.11.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Frictional Heat Powers Hydrothermal Activity on Enceladus

Computer simulation shows how the icy moon heats water in a porous rock core

Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Desert ants cannot be fooled

23.11.2017 | Life Sciences

By saving cost and energy, the lighting revolution may increase light pollution

23.11.2017 | Earth Sciences

Retreating permafrost coasts threaten the fragile Arctic environment

23.11.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>