Investigators at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Pfizer Global Research and Development and Stanford University have collaborated in studying a new immunosuppressant drug, CP-690,550, that may avoid some of the common side effects associated with other medications that curb the immune system. The new drug, discovered by Pfizer researchers, may be of major importance for those who are treated with immunosuppressants for organ transplants or autoimmune diseases.
John OShea, M.D., Yong-Jie Zhou, M.D., and their team in the NIAMS Molecular Immunology and Inflammation Branch joined scientists from Pfizer and Stanford in developing and studying the drug. CP-690,550 was tested in mice with heart transplants and in monkeys with kidney transplants done by Stanford. In both cases, animals treated with CP-690,550 survived much longer than untreated animals. None of the treated animals showed signs of such immunosuppressant side effects as increased cholesterol, blood sugar, blood pressure or increased white blood cell count. The animals also showed no significant decreases in white blood cells or platelets.
The new drug, reported in the journal Science, inhibits the enzyme Jak3, a protein discovered by the NIAMS team in 1994 that is found only in immune system cells. The new study shows that inhibiting this enzyme has the effect of suppressing the immune system, while not affecting other systems of the body. Current immunosuppressant drugs target enzymes found in cells throughout the body, resulting in the toxic side effects. The Jak3 inhibitor has the advantage of selectively targeting a protein that only has effects on immune cells.
NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases
Researchers identify key step in viral replication
13.03.2018 | University of Pittsburgh Schools of the Health Sciences
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.
When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...
At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.
Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...
16.03.2018 | Event News
13.03.2018 | Event News
08.03.2018 | Event News
16.03.2018 | Earth Sciences
16.03.2018 | Physics and Astronomy
16.03.2018 | Life Sciences