Discovery opens doors to treating symptom that can cause the body to attack itself
Researchers at the University of Pennsylvania School of Medicine have identified a variant of the human gene for tumor necrosis factor-alpha (TNF-alpha) as the cause for photosensitivity in lupus patients. This discovery, which was presented today at the annual scientific meeting of the American College of Rheumatology, will not only help in treating photosensitivity, but will also advance research on treating this potentially damaging symptom and possibly point to one of the genetic causes of lupus.
Victoria Werth, MD Associate Professor of Dermatology and Medicine in Penn’s School of Medicine, working in collaboration with Kathleen E. Sullivan, MD, PhD, Associate Professor of Pediatrics, University of Pennsylvania School of Medicine, and attending physician in The Children’s Hospital of Philadelphia Division of Allergy and Immunology, identified a variant of the TNF-alpha promoter that showed increased activity when exposed to sunlight. This discovery is crucial to understanding photosensitivity and lupus because TNF-alpha has been shown to stimulate apoptosis, the process of cellular death. As skin cells die, intracellular proteins move to the cell’s surfaces where they stimulate an immune reaction. The immune system makes new antibodies against these proteins and triggers further inflammation, causing the body to attack its own internal organs - just from sunlight.
Jen Miller | University of Pennsylvania
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University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
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