Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Outpatient treatment shrinks liver tumors to acceptable size for laser procedure

28.10.2003


Researchers in Germany are using a new combination treatment to first shrink and then kill liver tumors, according to a study appearing in the November issue of the journal Radiology.



The first part of the treatment, transarterial chemoembolization (TACE), is "a mixture of occlusion (closing off passages), reduction of the blood supply and chemotherapy to help decrease the size of the tumor," said study author Thomas J. Vogl, M.D., chairman of the Department of Diagnostic and Interventional Radiology at University Hospital Frankfurt, Germany.

Once the tumor is small enough, an interventional radiologist inserts laser fibers into the tumor and heats the tumor to 100 degrees in a procedure called laser-induced thermotherapy (LITT).


"This was initiated because we could not perform the laser therapy on tumors that were too large," Dr. Vogl said. "We see a lot of patients with liver tumors larger than 5 centimeters (about the size of a golf ball) and in the past we had to refuse them. We needed a way to reduce the tumor to a size where we could perform the laser treatment," he said.

Between March 1999 and December 2001, the researchers used TACE to treat 162 patients with liver tumors. Each patient underwent two to seven TACE treatments.

The largest tumor measured 80 millimeters (a little over 3 inches) in diameter before treatment. The size of each tumor was measured before and during treatment using magnetic resonance (MR) imaging. If the diameter of the tumor decreased to less than 50 millimeters (just under 2 inches), the patient was treated with MR image–guided LITT.

Eighty-two patients (51%) responded successfully to TACE, with a mean reduction in tumor size of 35 percent, and were treated with LITT. In 47 patients no reduction in tumor size was achieved, and in 33 patients disease progression was found, leading to further TACE treatments or change to systemic chemotherapy.

"This treatment is local," Dr. Vogl said. "With local chemotherapy, the patients have no pain and don’t lose their hair. This treatment allows us to be very aggressive in attacking the tumor, while maintaining a good quality of life for the patient," he said.

Median survival of patients who responded to this combined treatment was 26.2 months. In patients treated with only TACE, median survival was 12.8 months.

While Dr. Vogl and his colleagues have only used this combination treatment for liver tumors, he said it has applications for lung, bone and lymph node tumors as well. "These procedures are FDA accepted, and they’re starting to be used all over Europe," he said.


###
Radiology is a monthly scientific journal devoted to clinical radiology and allied sciences. The journal is edited by Anthony V. Proto, M.D., School of Medicine, Virginia Commonwealth University, Richmond, Virginia. Radiology is owned and published by the Radiological Society of North America Inc. (http://radiology.rsnajnls.org)

The Radiological Society of North America (RSNA) is an association of more than 33,000 radiologists, radiation oncologists and related scientists committed to promoting excellence through education and by fostering research, with the ultimate goal of improving patient care. The Society’s headquarters are located at 820 Jorie Boulevard, Oak Brook, Ill. 60523-2251. (http://www.rsna.org)

"Liver Metastases: Neoadjuvant Downsizing with Transarterial Chemoembolization before Laser-Induced Thermotherapy." Collaborating with Dr. Vogl on this paper were Martin G. Mack, M.D.; Jörn O. Balzer, M.D.; Kerstin Engelmann, M.D.; Ralf Straub, M.D.; Katrin Eichler, M.D.; Dirk Woitaschek, M.D.; and Stephan Zangos, M.D.; from the Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany.

Maureen Morley | EurekAlert!
Further information:
http://radiology.rsnajnls.org
http://www.rsna.org

More articles from Health and Medicine:

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

nachricht The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

Im Focus: Optoelectronic Inline Measurement – Accurate to the Nanometer

Germany counts high-precision manufacturing processes among its advantages as a location. It’s not just the aerospace and automotive industries that require almost waste-free, high-precision manufacturing to provide an efficient way of testing the shape and orientation tolerances of products. Since current inline measurement technology not yet provides the required accuracy, the Fraunhofer Institute for Laser Technology ILT is collaborating with four renowned industry partners in the INSPIRE project to develop inline sensors with a new accuracy class. Funded by the German Federal Ministry of Education and Research (BMBF), the project is scheduled to run until the end of 2019.

New Manufacturing Technologies for New Products

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Innovative LED High Power Light Source for UV

22.06.2017 | Physics and Astronomy

Mathematical confirmation: Rewiring financial networks reduces systemic risk

22.06.2017 | Business and Finance

Spin liquids − back to the roots

22.06.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>