Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Outpatient treatment shrinks liver tumors to acceptable size for laser procedure

28.10.2003


Researchers in Germany are using a new combination treatment to first shrink and then kill liver tumors, according to a study appearing in the November issue of the journal Radiology.



The first part of the treatment, transarterial chemoembolization (TACE), is "a mixture of occlusion (closing off passages), reduction of the blood supply and chemotherapy to help decrease the size of the tumor," said study author Thomas J. Vogl, M.D., chairman of the Department of Diagnostic and Interventional Radiology at University Hospital Frankfurt, Germany.

Once the tumor is small enough, an interventional radiologist inserts laser fibers into the tumor and heats the tumor to 100 degrees in a procedure called laser-induced thermotherapy (LITT).


"This was initiated because we could not perform the laser therapy on tumors that were too large," Dr. Vogl said. "We see a lot of patients with liver tumors larger than 5 centimeters (about the size of a golf ball) and in the past we had to refuse them. We needed a way to reduce the tumor to a size where we could perform the laser treatment," he said.

Between March 1999 and December 2001, the researchers used TACE to treat 162 patients with liver tumors. Each patient underwent two to seven TACE treatments.

The largest tumor measured 80 millimeters (a little over 3 inches) in diameter before treatment. The size of each tumor was measured before and during treatment using magnetic resonance (MR) imaging. If the diameter of the tumor decreased to less than 50 millimeters (just under 2 inches), the patient was treated with MR image–guided LITT.

Eighty-two patients (51%) responded successfully to TACE, with a mean reduction in tumor size of 35 percent, and were treated with LITT. In 47 patients no reduction in tumor size was achieved, and in 33 patients disease progression was found, leading to further TACE treatments or change to systemic chemotherapy.

"This treatment is local," Dr. Vogl said. "With local chemotherapy, the patients have no pain and don’t lose their hair. This treatment allows us to be very aggressive in attacking the tumor, while maintaining a good quality of life for the patient," he said.

Median survival of patients who responded to this combined treatment was 26.2 months. In patients treated with only TACE, median survival was 12.8 months.

While Dr. Vogl and his colleagues have only used this combination treatment for liver tumors, he said it has applications for lung, bone and lymph node tumors as well. "These procedures are FDA accepted, and they’re starting to be used all over Europe," he said.


###
Radiology is a monthly scientific journal devoted to clinical radiology and allied sciences. The journal is edited by Anthony V. Proto, M.D., School of Medicine, Virginia Commonwealth University, Richmond, Virginia. Radiology is owned and published by the Radiological Society of North America Inc. (http://radiology.rsnajnls.org)

The Radiological Society of North America (RSNA) is an association of more than 33,000 radiologists, radiation oncologists and related scientists committed to promoting excellence through education and by fostering research, with the ultimate goal of improving patient care. The Society’s headquarters are located at 820 Jorie Boulevard, Oak Brook, Ill. 60523-2251. (http://www.rsna.org)

"Liver Metastases: Neoadjuvant Downsizing with Transarterial Chemoembolization before Laser-Induced Thermotherapy." Collaborating with Dr. Vogl on this paper were Martin G. Mack, M.D.; Jörn O. Balzer, M.D.; Kerstin Engelmann, M.D.; Ralf Straub, M.D.; Katrin Eichler, M.D.; Dirk Woitaschek, M.D.; and Stephan Zangos, M.D.; from the Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany.

Maureen Morley | EurekAlert!
Further information:
http://radiology.rsnajnls.org
http://www.rsna.org

More articles from Health and Medicine:

nachricht Custom-tailored strategy against glioblastomas
26.09.2016 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New leukemia treatment offers hope
23.09.2016 | King Abdullah University of Science and Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New welding process joins dissimilar sheets better

Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of light metals.
Scientists at the University of Stuttgart have now developed two new process variants that will considerably expand the areas of application for friction stir welding.
Technologie-Lizenz-Büro (TLB) GmbH supports the University of Stuttgart in patenting and marketing its innovations.

Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of...

Im Focus: First quantum photonic circuit with electrically driven light source

Optical quantum computers can revolutionize computer technology. A team of researchers led by scientists from Münster University and KIT now succeeded in putting a quantum optical experimental set-up onto a chip. In doing so, they have met one of the requirements for making it possible to use photonic circuits for optical quantum computers.

Optical quantum computers are what people are pinning their hopes on for tomorrow’s computer technology – whether for tap-proof data encryption, ultrafast...

Im Focus: OLED microdisplays in data glasses for improved human-machine interaction

The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.

“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...

Im Focus: Artificial Intelligence Helps in the Discovery of New Materials

With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.

Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...

Im Focus: Complex hardmetal tools out of the 3D printer

For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.

Fraunhofer IKTS counts decades of proven expertise in the development of hardmetals. To date, reliable cutting, drilling, pressing and stamping tools made of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

European Health Forum Gastein 2016 kicks off today

28.09.2016 | Event News

Laser use for neurosurgery and biofabrication - LaserForum 2016 focuses on medical technology

27.09.2016 | Event News

Experts from industry and academia discuss the future mobile telecommunications standard 5G

23.09.2016 | Event News

 
Latest News

New imaging technique in Alzheimer’s disease - opens up possibilities for new drug development

28.09.2016 | Medical Engineering

Innovate coating extends the life of materials for industrial use

28.09.2016 | Materials Sciences

Blockchain Set to Transform the Financial Services Market

28.09.2016 | Business and Finance

VideoLinks
B2B-VideoLinks
More VideoLinks >>>