Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Outpatient treatment shrinks liver tumors to acceptable size for laser procedure

28.10.2003


Researchers in Germany are using a new combination treatment to first shrink and then kill liver tumors, according to a study appearing in the November issue of the journal Radiology.



The first part of the treatment, transarterial chemoembolization (TACE), is "a mixture of occlusion (closing off passages), reduction of the blood supply and chemotherapy to help decrease the size of the tumor," said study author Thomas J. Vogl, M.D., chairman of the Department of Diagnostic and Interventional Radiology at University Hospital Frankfurt, Germany.

Once the tumor is small enough, an interventional radiologist inserts laser fibers into the tumor and heats the tumor to 100 degrees in a procedure called laser-induced thermotherapy (LITT).


"This was initiated because we could not perform the laser therapy on tumors that were too large," Dr. Vogl said. "We see a lot of patients with liver tumors larger than 5 centimeters (about the size of a golf ball) and in the past we had to refuse them. We needed a way to reduce the tumor to a size where we could perform the laser treatment," he said.

Between March 1999 and December 2001, the researchers used TACE to treat 162 patients with liver tumors. Each patient underwent two to seven TACE treatments.

The largest tumor measured 80 millimeters (a little over 3 inches) in diameter before treatment. The size of each tumor was measured before and during treatment using magnetic resonance (MR) imaging. If the diameter of the tumor decreased to less than 50 millimeters (just under 2 inches), the patient was treated with MR image–guided LITT.

Eighty-two patients (51%) responded successfully to TACE, with a mean reduction in tumor size of 35 percent, and were treated with LITT. In 47 patients no reduction in tumor size was achieved, and in 33 patients disease progression was found, leading to further TACE treatments or change to systemic chemotherapy.

"This treatment is local," Dr. Vogl said. "With local chemotherapy, the patients have no pain and don’t lose their hair. This treatment allows us to be very aggressive in attacking the tumor, while maintaining a good quality of life for the patient," he said.

Median survival of patients who responded to this combined treatment was 26.2 months. In patients treated with only TACE, median survival was 12.8 months.

While Dr. Vogl and his colleagues have only used this combination treatment for liver tumors, he said it has applications for lung, bone and lymph node tumors as well. "These procedures are FDA accepted, and they’re starting to be used all over Europe," he said.


###
Radiology is a monthly scientific journal devoted to clinical radiology and allied sciences. The journal is edited by Anthony V. Proto, M.D., School of Medicine, Virginia Commonwealth University, Richmond, Virginia. Radiology is owned and published by the Radiological Society of North America Inc. (http://radiology.rsnajnls.org)

The Radiological Society of North America (RSNA) is an association of more than 33,000 radiologists, radiation oncologists and related scientists committed to promoting excellence through education and by fostering research, with the ultimate goal of improving patient care. The Society’s headquarters are located at 820 Jorie Boulevard, Oak Brook, Ill. 60523-2251. (http://www.rsna.org)

"Liver Metastases: Neoadjuvant Downsizing with Transarterial Chemoembolization before Laser-Induced Thermotherapy." Collaborating with Dr. Vogl on this paper were Martin G. Mack, M.D.; Jörn O. Balzer, M.D.; Kerstin Engelmann, M.D.; Ralf Straub, M.D.; Katrin Eichler, M.D.; Dirk Woitaschek, M.D.; and Stephan Zangos, M.D.; from the Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany.

Maureen Morley | EurekAlert!
Further information:
http://radiology.rsnajnls.org
http://www.rsna.org

More articles from Health and Medicine:

nachricht New study points the way to therapy for rare cancer that targets the young
22.11.2017 | Rockefeller University

nachricht Penn study identifies new malaria parasites in wild bonobos
21.11.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Frictional Heat Powers Hydrothermal Activity on Enceladus

Computer simulation shows how the icy moon heats water in a porous rock core

Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Underwater acoustic localization of marine mammals and vehicles

23.11.2017 | Information Technology

Enhancing the quantum sensing capabilities of diamond

23.11.2017 | Physics and Astronomy

Meadows beat out shrubs when it comes to storing carbon

23.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>