Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Case Western Reserve University scientists test protein as early cancer detection agent

23.10.2003


Scientists at Case Western Reserve University have identified an agent that could lead to the early detection of many cancers.



The Case research team discovered that the human body increases production of the protein clusterin as a signal of cell distress and provides a reliable gauge of the general health of a cell. The findings were reported in a recent issue of the scientific journal Cancer Biology and Therapy.

"Understanding the processes that create this protein after radiation therapy or other treatments for cancer is important in our quest to develop new therapy regimens that improve the chances of recovery," said David Boothman, professor of radiation oncology and pharmacology and associate director of basic research at Case and University Hospitals of Cleveland.


According to the study, clusterin should behave in blood as it does in cells examined in the laboratory. The team observed clusterin levels rise in response to the presence of cancer. Researchers said this rise would indicate that if a baseline clusterin level was established for a healthy person, a simple blood test could detect any deviation in clusterin levels, indicating the potential presence of cancer. Case researchers will continue studies to confirm the findings and gain additional information.

The researchers used cells from humans and mice to establish their findings. "Trying to understand how genes influence cancer requires either a guess or mice, because we can’t expose humans to the radiation that helped us get to these findings. Humans and mice share many genes, so it was much easier to use strains of genetically identical mice," Boothman said.

Case scientists test protein as early cancer detection.... add one

To monitor clusterin expression in human and rodent cells, the researchers made a gene cassette in which they fused the clusterin gene to luciferase, the enzyme that provides the light in fireflies. They implanted the bound gene cassette into cancerous breast cells and then implanted the cancerous cells or tissue into mice, which they irradiated. They then observed the behavior of the genetic material to learn more about clusterin expression.

Boothman’s team is also working to develop a simple blood test that would identify clusterin levels, and to test its ability to identify cancer in mouse models.


Boothman worked with co-investigators David Wilson, professor of biomedical engineering; Helen Evans, professor of radiation oncology; Andrew Rollins, assistant professor of biomedical engineering; Lindsey Mayo, assistant professor of radiation oncology; Dmitry Klokov, Konstantin Leskov, and Shinako Araki, post-doctoral research associates; and Tracy Criswell, a graduate student in pathology at the Case School of Medicine.

About Case Western Reserve University
Case is among the nation’s leading research institutions. Founded in 1826 and shaped by the unique merger of the Case Institute of Technology and Western Reserve University, Case is distinguished by its strengths in education, research, and service. Located in Cleveland, Case offers nationally recognized programs in the Arts and Sciences, Dentistry, Engineering, Law, Management, Medicine, Nursing, and Social Sciences.

Marci Hersh | EurekAlert!
Further information:
http://www.case.edu

More articles from Health and Medicine:

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>