Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

High doses of radiation found to be effective, with few side effects

21.10.2003


New research shows that men with clinically localized prostate cancer, treated to high dose levels with three-dimensional conformal radiation therapy (3D-CRT), achieved long-term PSA relapse-free survival (PRFS) with minimal side effects. Researchers from Memorial Sloan-Kettering Cancer Center (MSKCC) presented findings from the 10-year retrospective study today at the 45th Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO) in Salt Lake City, Utah.



"This is the first study that is looking at 10-year results of dose escalation with 3D-CRT and demonstrating improved outcomes in all subgroups of patients treated with high doses of radiation compared to lower conventional dose levels," said the study’s lead author Michael Zelefsky, MD, Chief of MSKCC’s Brachytherapy Service. "We observed that the radiation dose was one of the critical ingredients, or predictors, for achieving improved outcome and enhanced disease control rates in each of the patient groups we evaluated."

Researchers analyzed data from 828 MSKCC patients treated between 1988 and 1997. The patients were categorized into prognostic risk groups based on pre-treatment PSA levels, Gleason score, and clinical stage. At 10 years, the PRFS outcomes for favorable, intermediate, and unfavorable risk patients were 70 percent, 49 percent, and 35 percent respectively. Higher radiation dose levels (the doses in the study ranged from 64.8 Gy up to 75.6 Gy) were associated with an improved PRFS at 10 years for each prognostic group.


The other significant finding of the study is that patients had minimal side effects, despite the fact that higher doses of radiation were delivered. The long-term risk of serious rectal or bladder injuries at 10 years was 2 ½ percent and 1 ½ percent, respectively. "This dispels the notion that as time goes on the side effects become more noticeable and patients are more at risk for developing long-term damage years out from treatment," said Dr. Zelefsky.

"Radiation dose has a significant impact on the outcome of patients with localized prostate cancer treated with radiation therapy. We continue to observe that even higher doses have further improved cure rates for patients with localized prostate cancer," said Steven Leibel, MD, Chairman of MSKCC’s Department of Radiation Oncology and the study’s senior author. "These mature data show that even 10 years from the therapy, despite the application of high radiation doses, the tolerance was excellent."


Memorial Sloan-Kettering Cancer Center is the world’s oldest and largest institution devoted to prevention, patient care, research and education in cancer. Our scientists and clinicians generate innovative approaches to better understand, diagnose and treat cancer. Our specialists are leaders in biomedical research and in translating the latest research to advance the standard of cancer care worldwide.

Esther Carver | EurekAlert!
Further information:
http://www.mskcc.org/

More articles from Health and Medicine:

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

nachricht The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

IHP presents the fastest silicon-based transistor in the world

05.12.2016 | Power and Electrical Engineering

InLight study: insights into chemical processes using light

05.12.2016 | Materials Sciences

High-precision magnetic field sensing

05.12.2016 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>