Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Proteins enable HIV to override cell’s defenses

17.10.2003


Discovery of protein chain may lead to new drugs and treatments



Researchers at the Johns Hopkins Bloomberg School of Public Health have identified a complex series of proteins that enable HIV to bypass the natural defenses of human cells and replicate. The discovery of these proteins is the key for understanding how HIV overcomes host defenses and could potentially be new targets for HIV medications. A study detailing the finding is published in the October 16, 2003, online version of the journal Science.

As the researchers explained in their article, viruses like HIV contain a viral infectivity factor (Vif), which is essential for evading the human cell’s natural antiviral agent called APOBEC3G. To disable the antiviral agent, Vif interacts with a series of proteins to modify (polyubiquitination) and degrade APOBEC3G. Xiao-Fang Yu, MD, DSc, an associate professor with the School’s Department of Molecular Microbiology and Immunology, and his colleagues have identified these proteins as Cullin5, Elongins B and C and Rbx1. Together, they form a complex of proteins called ubiquitin E3 ligase (Cul5-SCF), which interacts with Vif and APOBEC3G.


"We’ve discovered a new link in the chain that allows the HIV to overcome the cellular resistant factor and to infect human cells," said Dr. Yu. "By identifying the proteins involved in this process, we may be able to develop new drugs and therapies for preventing HIV infection."

Through a series of laboratory experiments, Dr. Yu’s team further found that disruption of the Cul5-SCF function makes HIV less infectious and less able of suppress APOBEC3G and its protective properties. HIV infectiousness was reduced 90 percent when Cul5 mutants were over expressed in combination with APOBEC3G.

Dr. Yu and his collaborators, Drs. Xianghui Yu, Yunkai Yu, Bindong Liu and Kun Luo, are working on further explaining the mechanism of Vif and Cul5 complex interaction and identifying strategies to block Vif function and consequently HIV infection.


"Induction of Ubiquitination and Degradation of APOBEC3G by HIV-1 Vif-Cul5-SCF" was written by Xianghui Yu, Yunkai Yu, Bindong Liu, Kun Luo, Wei Kong, Panyong Mao and Xiao-Fang Yu.

The study was funded by grants from National Center for Research Resources. Reagents were supplied by the AIDS Research Reagent Program, division of AIDS, NIAID, NIH.

Tim Parsons | EurekAlert!
Further information:
http://www.jhsph.edu/Press_Room

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>