Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene mutation responsible for Chrohn’s disease inflammation identified in Temple study

16.10.2003


A mutation in one of the genes that might be responsible for the inflammation that characterizes Crohn’s disease has been identified by researchers at Temple University’s School of Medicine (TUSM).



Their study, "The mutation Ser511Asn leads to N-glycosulation and increases the cleavage of high molecular weight kininogen in rats genetically susceptible to inflammation," appears in the October 15 issue of Blood (www.bloodjournal.org).

Although the exact cause of Crohn’s disease, a digestive disorder afflicting approximately 500,000 adults in the U.S., remains unknown, scientists agree that it is governed by the immune system and has a genetic component.


"Everyone has bacteria throughout their digestive tract, but in people with Crohn’s disease, bacterial products activate inflammation, as well as the immune system, which leads to the debilitating symptoms of Crohn’s, including diarrhea, constipation and cramps," said Robert Colman, MD, professor of medicine at TUSM and lead investigator of the study. "Since this reaction doesn’t occur in everyone, we suspected that there was a genetic component."

While other researchers have found several genes that indicate an increased susceptibility to Crohn’s disease, the Temple study went a step further and explored the role of genetics in causing the inflammation that characterizes the disease.

Specifically, Temple researchers identified a genetic mutation that involves one of the proteins (kininogen) known to be involved in inflammation. In a previous study, Colman demonstrated that a deficiency in this protein led to a much milder form of inflammation.

"Finding this mutation is important because we are now in a position to look for the same genetic mutations in humans, the presence of which would confirm that the protein kininogen plays an important role in the origin and development of Crohn’s. We could then direct therapy toward modifying the effects of this protein," said Colman.

Temple researchers collaborated with the Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, Chapel Hill. The study was supported by funding from the National Institutes of Health and the Crohn’s and Colitis Foundation.

Eryn Jelesiewicz | EurekAlert!
Further information:
http://www.temple.edu/
http://www.bloodjournal.org

More articles from Health and Medicine:

nachricht Minimising risks of transplants
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

nachricht FAU researchers demonstrate that an oxygen sensor in the body reduces inflammation
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Stiffness matters

22.02.2018 | Life Sciences

Magnetic field traces gas and dust swirling around supermassive black hole

22.02.2018 | Physics and Astronomy

First evidence of surprising ocean warming around Galápagos corals

22.02.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>