Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New treatment improves long-term outlook for breast cancer survivors

10.10.2003


A Canadian-led international clinical trial has found that post-menopausal survivors of early-stage breast cancer who took the drug letrozole after completing an initial five years of tamoxifen therapy had a significantly reduced risk of cancer recurrence compared to women taking a placebo. The results of the study appear in today’s advance on-line edition of the New England Journal of Medicine.



The clinical trial has been halted early because of the positive results and researchers are notifying the 5,187 women worldwide who have participated in the study. Women on letrozole will continue taking the drug and those on the placebo can begin taking letrozole, if they wish.

"This very important advance in breast cancer treatment will improve the outlook for many thousands of women," said Andrew von Eschenbach, M.D., director of the National Cancer Institute which led the study in the United States. "This is one more example of the ability to interrupt the progression of a cancer using a drug that blocks a crucial metabolic pathway in the tumor cell."


Study researchers found that letrozole, when taken after five years of tamoxifen therapy, substantially increased the chance of remaining cancer free. In total, 132 women taking the placebo had their disease recur compared to 75 on letrozole. Overall, letrozole reduced the risk of recurrence by 43 percent, so that after four years of participating in the trial, 13 percent of the women on the placebo, but only seven percent, of those on letrozole had recurred. Deaths from breast cancer were also reduced. Seventeen women taking the placebo died of breast cancer compared to nine taking letrozole.

While tamoxifen is widely used to prevent breast cancer recurrence in post-menopausal women, it stops being effective after five years because, researchers believe, tumours become resistant to it.

"More than half of women who develop recurrent breast cancer do so more than five years after their original diagnosis," says Paul Goss, M.D., of Princess Margaret Hospital in Toronto. "For years, we have thought that we had reached the limit of what we could do to reduce the risk of recurrence with five years of tamoxifen. Our study ushers in a new era of hope by cutting these ongoing recurrences and deaths from breast cancer after tamoxifen by almost one half." Goss, a leading expert in novel hormone therapies for the treatment and prevention of breast cancer, conceived and chaired the international trial with letrozole.

A form of hormone therapy for the treatment of breast cancer, letrozole works by limiting the ability of an enzyme called aromatase to produce estrogen, a major growth stimulant in many breast cancers.

Mayo Clinic medical oncologist James Ingle, M.D., says, "Based on our findings, all post-menopausal women with hormone-receptor positive tumours completing about five years of tamoxifen should discuss taking letrozole with their doctors to reduce their risk of breast cancer recurrence." Ingle, from Rochester, Minn., led the research study in the United States.

With Canadian Cancer Society funding, the clinical trial was coordinated by the National Cancer Institute of Canada Clinical Trials Group at Queen’s University, in partnership with the U.S. National Cancer Institute and its Clinical Trials Cooperative Groups. Novartis, which manufactures letrozole, also known as Femara®, provided the drug for the trial.

Women participated in the study for an average of 2.4 years and for as long as five years. The study found that women taking letrozole had a reduction in the number of recurrences of cancer in their previously affected breast, a reduction in the number of new cancers in their opposite breast, and a reduction in the spread of the cancer outside their breast.

The side effects of letrozole, a pill which is taken once a day, are very similar to those experienced by women undergoing menopause. They were generally mild in study participants. Women in the study will continue to be followed to more thoroughly assess any effects of long-term use of letrozole on bone strength or other organs. Until these are known, patients should be monitored closely.

"The Canadian Cancer Society is pleased to have made a key contribution to this study," says Barbara Whylie, M.D., director of Cancer Control Policy for the Canadian Cancer Society. "We estimate that more than 20,000 Canadian women will be diagnosed with breast cancer this year and just over half of those are going to be eligible for this drug. That means these women will have a significantly improved hope for a future without cancer."

"This large trial only began in 1998 and we already have important results that will change clinical practice," says Jeffrey Abrams, M.D., coordinator of the U.S. National Cancer Institute’s Cooperative Group breast cancer treatment trials. "This is a tribute to the patients and physicians who participated since their efforts will now have a positive impact on so many lives."

Participants in the clinical trial were enrolled through hospitals, cancer centers and institutes throughout Canada, the United States, England, Belgium, Ireland, Italy, Poland, Portugal and Switzerland. The European Organization for Research and Treatment of Cancer and the International Breast Cancer Study Group coordinated the European component of the trial.


The Canadian Cancer Society is the largest charitable funder of cancer research in Canada. It funds clinical trials research through its support of the National Cancer Institute of Canada Clinical Trials Group.

The National Cancer Institute is the primary U.S. agency for cancer research

NCI Press Officers | EurekAlert!
Further information:
http://cancer.gov/newscenter/pressreleases/letrozoleQandA
http://cancer.gov/clinicaltrials/developments/aromatase-inhibitors-digest

More articles from Health and Medicine:

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

nachricht The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>