Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

White blood cell plays key role in body’s excessive repair response to asthma

02.10.2003


Airway scarring can be disrupted by targeting eosinophils



Researchers in London and Montreal report today that they have discovered an important link in the development of the body’s response to allergic asthma.
They have found that one type of white blood cell, an eosinophil, which was known to cause inflammation of lung airways, is also responsible for driving the process which leads to an excessive ’repair response’ by the body.

The response, which is called airway remodelling, causes structural changes in the airway walls and can sometimes lead to permanent scarring and narrowing of the airways, resulting in worse and repeated asthma episodes for sufferers.



The team of scientists from Imperial College London, the Royal Brompton Hospital, London, Guys Hospital, London, McGill University Hospital Centre, Montreal, and St Barts and the Royal London Hospitals Trust, report that the damaging effects of eosinophils in the remodelling process can be significantly reduced by injection of a single specific antibody.

Their research published today in the Journal of Clinical Investigation shows that the monoclonal antibody anti-Interleukin-5 (mepolizumab) both reduces the number of eosinophils in the bronchi and significantly decreases the deposition of special proteins associated with the remodelling process.

The scientists hope their work may lead to the development of ’really effective’ new asthma treatments that work by interfering with the remodelling process.

Leader of the research, Professor Barry Kay, of Imperial College London and the Royal Brompton Hospital, comments: "This research could be of considerable long term benefit in developing more effective treatments in asthma. We already know that eosinophils cause inflammation in the bronchi, but it is the subsequent repair process which may be more important in long term chronic disease.

"In the future, drugs may be available which completely interfere with the process of scarring or re-modelling, and may prove beneficial in the long term treatment of asthma."

Professor Kay adds: "Anti-IL-5 will not be a magic bullet for asthma sufferers, but it could be an important first step in developing really effective drugs which interfere with re-modelling."

Anti-IL5, which removes Interleukin-5, a key molecule in eosinophil development, was given to mild asthmatics as part of a randomised, double blind, placebo controlled protocol.

The 24 patients in the study received three infusions of either the antibody or a placebo dummy injection one month apart, and had a biopsy of the lining of the breathing tubes before and after each infusion. The scientists measured levels of extra cellular matrix (ECM) proteins in the biopsy samples, which indicated the levels of remodelling activity in the airway.


The research was supported by grants from GlaxoSmithKline plc and the Wellcome Trust.

Tony Stephenson | EurekAlert!
Further information:
http://www.imperial.ac.uk

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Safe glide at total engine failure with ELA-inside

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

New pop-up strategy inspired by cuts, not folds

27.02.2017 | Materials Sciences

Sandia uses confined nanoparticles to improve hydrogen storage materials performance

27.02.2017 | Interdisciplinary Research

Decoding the genome's cryptic language

27.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>