Many medications such as therapeutic DNA, insulin and human growth hormone must enter the body through painful injections, but a Johns Hopkins researcher is seeking to deliver the same treatment without the sting. Justin Hanes wants to pack the drugs inside microscopic plastic spheres that can be inhaled painlessly. Inside the lungs, the particles should dissolve harmlessly, releasing the medicine at a predetermined pace.
"Weve made significant progress," said Hanes, an assistant professor in the Whiting School of Engineerings Department of Chemical and Biomolecular Engineering, "especially when you consider all of the challenges weve faced in designing and synthesizing these new biomaterials."
For one thing, the polymers used in making such particles must dissolve slowly in the body, releasing the medicine over a prescribed period of hours, days or even weeks. Also, these materials must be strong and flexible, so that the particles do not crack or crumble before delivering their treatment. At the same time, the particles must not stick together, forming clumps that will prevent proper travel through the air passages. Once the particles deposit in the lungs, some therapies will require that they cross the thick mucus lining of air passages prior to releasing their medicinal cargo. Finally, the materials must not trigger a strong immune response, in which the bodys natural defense system attacks a particle before it has delivered its dose.
Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University
The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
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