Many medications such as therapeutic DNA, insulin and human growth hormone must enter the body through painful injections, but a Johns Hopkins researcher is seeking to deliver the same treatment without the sting. Justin Hanes wants to pack the drugs inside microscopic plastic spheres that can be inhaled painlessly. Inside the lungs, the particles should dissolve harmlessly, releasing the medicine at a predetermined pace.
"Weve made significant progress," said Hanes, an assistant professor in the Whiting School of Engineerings Department of Chemical and Biomolecular Engineering, "especially when you consider all of the challenges weve faced in designing and synthesizing these new biomaterials."
For one thing, the polymers used in making such particles must dissolve slowly in the body, releasing the medicine over a prescribed period of hours, days or even weeks. Also, these materials must be strong and flexible, so that the particles do not crack or crumble before delivering their treatment. At the same time, the particles must not stick together, forming clumps that will prevent proper travel through the air passages. Once the particles deposit in the lungs, some therapies will require that they cross the thick mucus lining of air passages prior to releasing their medicinal cargo. Finally, the materials must not trigger a strong immune response, in which the bodys natural defense system attacks a particle before it has delivered its dose.
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More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
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The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
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