Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Making tiny plastic particles to deliver lifesaving medicine

29.09.2003


Many medications such as therapeutic DNA, insulin and human growth hormone must enter the body through painful injections, but a Johns Hopkins researcher is seeking to deliver the same treatment without the sting. Justin Hanes wants to pack the drugs inside microscopic plastic spheres that can be inhaled painlessly. Inside the lungs, the particles should dissolve harmlessly, releasing the medicine at a predetermined pace.



"We’ve made significant progress," said Hanes, an assistant professor in the Whiting School of Engineering’s Department of Chemical and Biomolecular Engineering, "especially when you consider all of the challenges we’ve faced in designing and synthesizing these new biomaterials."

For one thing, the polymers used in making such particles must dissolve slowly in the body, releasing the medicine over a prescribed period of hours, days or even weeks. Also, these materials must be strong and flexible, so that the particles do not crack or crumble before delivering their treatment. At the same time, the particles must not stick together, forming clumps that will prevent proper travel through the air passages. Once the particles deposit in the lungs, some therapies will require that they cross the thick mucus lining of air passages prior to releasing their medicinal cargo. Finally, the materials must not trigger a strong immune response, in which the body’s natural defense system attacks a particle before it has delivered its dose.


Hanes and his lab colleagues have overcome many of these hurdles, publishing their research results in peer-reviewed journals. Last year, in an issue of "Biomaterials," Hanes’ team, including associate research scientist Jie Fu and doctoral candidate Jennifer Fiegel, reported that it had synthesized a new type of porous polymer particles capable of releasing drugs in an environment resembling the deep lungs. Importantly, the components used to create these plastic microspheres were materials already FDA-approved for other medical applications, making it more likely they will pose no health hazards to humans in their new polymeric form.

Recent work by Hanes, doctoral candidate Michelle Dawson and associate professor Denis Wirtz has focused on understanding how to alter the design of drug-carrying particles so that they can more efficiently cross the mucus lining in the lungs to reach their cell targets underneath. Reports on this work are expected appear shortly in the "Journal of Biology Chemistry," "Biotechnology Progress" and the "Journal of Aerosol Medicine."

Earlier this year, in "Proceedings of the National Academy of Sciences," Hanes, Wirtz and Junghae Suh, a doctoral candidate, reported that their nanoscopic particles appear to be able to efficiently deliver therapeutic genes by carrying DNA directly to the cell nucleus. Someday, Hanes said, this technique also may prove useful in delivering toxic cancer-fighting drugs only to cells affected by the disease.

For his research accomplishments, Hanes is being recognized in the October issue of MIT’s "Technology Review" as one of the world’s top 100 young innovators. The TR100, chosen by the publication’s editors and an elite panel of judges, consists of 100 individuals under 35 whose innovative work in technology has a profound impact on today’s world. Nominees are recognized for their contributions in transforming the nature of technology in industries such as biotechnology, computing, energy, medicine, manufacturing, nanotechnology, telecommunications and transportation. This marks the second consecutive year that a Johns Hopkins engineering faculty member has appeared on the TR100. Last year, the magazine singled out Jennifer Elisseeff, assistant professor of biomedical engineering, for her research in the field of tissue engineering.

Hanes has focused much of his attention on the lungs because they possess several advantages over other drug delivery routes. When medicine is swallowed, it must pass through the stomach, where it may be degraded by digestive acids. Injections may avoid this problem, but they also are painful and may be difficult for some patients to administer to themselves. Inhalation, however, as smokers and asthmatics know, is generally a quick and painless method of getting a drug into the body. Still, Hanes noted, "the lungs are pretty sacred ground. You have to be very conservative about what you put in there."

As a doctoral student at MIT, Hanes played a leading role in developing porous polymer drug delivery particles coated with a special surfactant native to the lung. The surfactant is designed to fool the body into thinking these particles belong in the lungs, warding off an immune response. In 1999, Hanes and his colleagues received a U.S. patent for this invention; Hanes currently holds eight U.S. patents for advanced drug delivery applications.

At Johns Hopkins, he is building upon this research by synthesizing improved inhalation particles, each about a tenth of the diameter of a human hair. He soon hopes to begin testing their safety and effectiveness in animal models and eventually in human trials. Hanes also is trying to produce even smaller particles that could be used to deliver powerful medications directly into diseased cells, while leaving normal tissue unharmed.

Hanes’ early research has been supported by several grants and awards, including one from the Whitaker Foundation.

Phil Sneiderman | EurekAlert!
Further information:
http://www.jhu.edu/
http://www.jhu.edu/~cheme/hanes/index.html
http://www.jhu.edu/chbe/index.asp

More articles from Health and Medicine:

nachricht 'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS

nachricht New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Rare find from the deep sea

20.02.2018 | Life Sciences

In living color: Brightly-colored bacteria could be used to 'grow' paints and coatings

20.02.2018 | Life Sciences

Observing and controlling ultrafast processes with attosecond resolution

20.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>