Scientists used to think that fibroblasts – the cells that form basic tissue structures – were little more than scaffolding on which more important cells would climb. But University of Rochester Medical Center scientists have discovered that certain fibroblasts have highly specialized duties and play a major role in how scars form, fat accumulates, and harmful inflammation arises in humans.
The research is published in The American Journal of Pathology, October 2003 edition. The work may help doctors understand why some people suffer from unexplained internal scarring around vital organs, which can lead to serious diseases of the eyes, lungs, heart, kidneys or intestines. It may tell us why some accident victims and surgical patients scar easily and take longer to heal. Ultimately, the goal of the research is to pave the way toward drugs that stop unhealthy scars or fatty tissue from developing.
"This is the first clear demonstration that certain kinds of human fibroblasts can develop into scar-type or fat-type cells," says Richard P. Phipps, Ph.D., lead author and professor, Environmental Medicine, Microbiology and Immunology, Oncology and Pediatrics. "In fact, our results show that some fibroblasts may prove to be a useful diagnostic tool by providing clues to the severity of a disease or who might be prone to abnormal wound healing, for example."
Leslie Orr | EurekAlert!
NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
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Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
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For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
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