Scientists used to think that fibroblasts – the cells that form basic tissue structures – were little more than scaffolding on which more important cells would climb. But University of Rochester Medical Center scientists have discovered that certain fibroblasts have highly specialized duties and play a major role in how scars form, fat accumulates, and harmful inflammation arises in humans.
The research is published in The American Journal of Pathology, October 2003 edition. The work may help doctors understand why some people suffer from unexplained internal scarring around vital organs, which can lead to serious diseases of the eyes, lungs, heart, kidneys or intestines. It may tell us why some accident victims and surgical patients scar easily and take longer to heal. Ultimately, the goal of the research is to pave the way toward drugs that stop unhealthy scars or fatty tissue from developing.
"This is the first clear demonstration that certain kinds of human fibroblasts can develop into scar-type or fat-type cells," says Richard P. Phipps, Ph.D., lead author and professor, Environmental Medicine, Microbiology and Immunology, Oncology and Pediatrics. "In fact, our results show that some fibroblasts may prove to be a useful diagnostic tool by providing clues to the severity of a disease or who might be prone to abnormal wound healing, for example."
Leslie Orr | EurekAlert!
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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