Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

First steps towards a vaccine for pancreatic cancer

22.09.2003


Research carried out in the United States has raised the hope that one day there could be a vaccine against pancreatic cancer – one of the most difficult cancers to treat successfully.



Dr Robert Maki told ECCO12 – The European Cancer Conference - today (Monday 22 September) that preliminary work with a cancer vaccine created from a heat-shock protein1 taken from the patient’s own tumour had resulted in one patient out of the ten vaccinated still alive and without disease after five years, and two more alive and without disease after more than two years. The typical survival after surgery for pancreas cancer is 14-15 months.

However, Dr Maki warned that patients should not get excited about the results of this research as it was too early to tell whether it would be possible to create a vaccine that could be used on all pancreatic cancer patients, and the patients involved in the trial had been carefully selected and might have been ones that would have done well anyway.


Dr Maki, an assistant member in the division of GI oncology in the department of medicine, and co-director of the sarcoma programme at the Memorial Sloan-Kettering Cancer Center in New York, USA, told delegates that he and his colleagues had run a phase I trial on 10 pancreatic patients using a vaccine based on a heat-shock protein called HSPPC-96 taken from the tumour of each patient (i.e. autologous).

Initial problems in creating the vaccine meant that the study was delayed half way through the study to improve the vaccine-making process. Dr Maki said: “The problem is that the pancreas makes digestive enzymes that destroy proteins . . . in other words, the pancreatic tumour cells themselves can destroy the vaccine you are trying to make, if you do not handle the tumour tissue carefully and quickly. With improvement in the vaccine purification process, most patients with the primary pancreatic cancer enrolled on the study were able to receive vaccinations.”

First, surgeons operated to remove completely the primary tumour, and then the patients were vaccinated within eight weeks of surgery. As far as doctors could tell, the patients were disease-free at the time of their vaccinations. None of the patients suffered side effects that limited the dose of the vaccine, and none had chemotherapy or radiotherapy.

Dr Maki said: “Tests on the patients showed that at least some people we examined made a response against the vaccine and therefore, hopefully, against the cancer. However, we will only get a better picture of the efficacy of this vaccine when we have the clinical results from a larger study.” The overall survival for the 10 patients was two and a half years, in comparison to 14.3 months, the historical average.

“Over 95% of people with pancreatic cancer die, typically within two years of diagnosis, and mortality is still about 90% even for those who have complete removal of their pancreatic cancer. So the finding of even a few patients surviving two years or more is promising regarding the usefulness of this vaccine after removal of the cancer. However, and this is a big however, we may be biased in who we selected for the study. Only people who could have an operation were eligible; we screened out people who had evidence of spread of tumor before they entered the study. Perhaps, just by chance, we got a few people who were destined to do well. So enthusiasm about any phase II study has to be tempered by the fact that you need a proper randomized study to determine the vaccine’s usefulness,” he said.

HSPPC-96 has been shown to have quite a dramatic effect in some patients with metastatic melanoma and so Dr Maki hopes that trials could be run to further test its efficacy against pancreatic cancer as well. In the meantime, until a larger study has been run, it will not be known for certain whether this vaccine has real potential against pancreatic cancer. Trials are also underway to test the vaccine in the treatment of kidney cancer.

The story of this vaccine is a good example of how earlier discoveries at the lab bench can eventually translate into potential new therapies for patients. Dr Maki’s PhD was based on cloning and purifying the human HSPCC-96 molecule. “It is nice to see that well over 10 years after my PhD, this interesting molecule is undergoing examination in the clinic. It is gratifying to see the studies move from the bench to patients, where I hope some benefit will be seen. Similarly, this same technique could be used in preparing vaccines against infectious diseases – another very large area of potential use for these vaccines.”

Mary Rice | alfa
Further information:
http://www.fecs.be/conferences/ecco12/media_updates.shtml

More articles from Health and Medicine:

nachricht Chances to treat childhood dementia
24.07.2017 | Julius-Maximilians-Universität Würzburg

nachricht World first: Massive thrombosis removed during early pregnancy
20.07.2017 | Universitätsspital Bern

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

Ultrathin device harvests electricity from human motion

24.07.2017 | Power and Electrical Engineering

Scientists announce the quest for high-index materials

24.07.2017 | Materials Sciences

ADIR Project: Lasers Recover Valuable Materials

24.07.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>