Total lymphocyte count and hemoglobin concentration lowers at onset of the disease
People with HIV and their physicians could have a less expensive tool to track the progression from HIV infection to AIDS. According to researchers from the Johns Hopkins Bloomberg School of Public Health, a decline in the total lymphocyte counts (TLC) and hemoglobin (Hgb) concentration in the blood may be used to monitor a patients disease status. Currently, HIV RNA and CD4+ cells in the blood are measured. However, specialized equipment and training for lab technicians makes these measurements expensive. TLC and Hgb measurements are much less expensive and can be obtained by using standard blood tests. "Rapid declines in total lymphocyte counts and hemoglobin concentration prior to AIDS among HIV-1-infected men," appears in the September 2003 issue of the journal AIDS, the official journal of the International AIDS Society.
The studys lead author, Bryan Lau, a graduate student in the Schools Department of Epidemiology, said, "This study demonstrates that there is a biological event that occurs during the progression of HIV infection leading to declines in TLC and Hgb within individuals. The majority of HIV individuals who develop AIDS experience a rapid decline in total lymphocyte counts and hemoglobin concentration that starts about one and one-half years prior to developing AIDS. The decline in these two markers in individuals who develop AIDS shows that this is an important event in the pathogenesis of the disease."
Kenna Brigham | EurekAlert!
NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases
Researchers identify key step in viral replication
13.03.2018 | University of Pittsburgh Schools of the Health Sciences
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
19.03.2018 | Event News
16.03.2018 | Event News
13.03.2018 | Event News
21.03.2018 | Physics and Astronomy
21.03.2018 | Materials Sciences
21.03.2018 | Life Sciences