Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


18F-FLT more accurate than 18F-FDG for differentiating unclear lung lesions


Lung cancer is the leading cause of cancer death in both men and women. To successfully fight the disease, doctors use a variety of techniques to diagnose the cancer and determine the extent of its spread throughout the body. When using positron emission tomography (PET) as a diagnostic tool, 18F-FDG has proven to be a reliable and accurate tracer, but false positives have been noted in areas of inflammation. Recently, German researchers conducted a study comparing the results of 18F-FDG PET and 18F-FLT PET and found the latter to be a more precise indicator for diagnosing unclear lung lesions.

The study, published in the September 2003 issue of The Journal of Nuclear Medicine, included examinations of 26 patients with pulmonary nodules revealed on chest CT. Subsequent biopsies confirmed that eighteen of the patients involved had malignant tumors, and eight had benign tumors. Using standardized uptake value (SUV), tumoral uptake was calculated for both 18F-FDG PET and 18F-FLT PET.

Results revealed 18F-FLT SUV correlated better than18F-FDG SUV with the proliferation index. This confirms the theory that 18F-FLT, a tracer specifically designed to reveal the presence of malignant tumors, is better at differentiating cancerous growths from other lesions. While the results show promise for the use of 18F-FLT, they do not indicate 18F-FLT can replace 18F-FDG, which is quite accurate in staging tumors.

In his invited commentary, Anthony F. Shields, MD, PhD of Karmanos Cancer Institute, Wayne State University School of Medicine, indicates more clinical trials are needed to further evaluate 18F-FLT, as well as other tracers that can supplement the information provided by 18F-FDG.

"Imaging Proliferation in Lung Tumors with PET: 18F-FLT vs. 18F-FDG" was written by Andreas K. Buck, MD, Holger Schirrmeister, MD, Jörg Kotzerke, MD, Gerhard Glatting, PhD, Bernd Neumaier, PhD, and Sven N. Reske, MD from the Department of Nuclear Medicine; Gisela Halter, MD and Imke Wurziger, of the Department of Thoracic Surgery; Torsten Mattfeldt, MD, of the Department of Pathology; and Martin Hetzel, MD, of the Department of Internal Medicine II, all from the University of Ulm in Ulm, Germany.

Copies of the article and images related to the study are available to media upon request to Kimberly A. Bennett. Current and past issues of The Journal of Nuclear Medicine can be found online at Print copies can be obtained at $15 per copy by contacting the SNM Service Center, Society of Nuclear Medicine, 1850 Samuel Morse Drive, Reston, VA 20190-5315; phone: (703) 326-1186; fax: (703) 708-9015; email: A yearly subscription to the journal is $210 for individuals and $318 for institutions. A subscription is a Society of Nuclear Medicine member benefit.

The Society of Nuclear Medicine is an international scientific and professional organization of more than 14,000 members dedicated to promoting the science, technology, and practical applications of nuclear medicine. The SNM is based in Reston, VA.

Kimberly A. Bennett | EurekAlert!
Further information:

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Space observation with radar to secure Germany's space infrastructure

Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.

The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...

Im Focus: Researchers Discover New Anti-Cancer Protein

An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.

The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...

Im Focus: Researchers at Fraunhofer monitor re-entry of Chinese space station Tiangong-1

In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.

Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...

Im Focus: Alliance „OLED Licht Forum“ – Key partner for OLED lighting solutions

Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.

They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...

Im Focus: Mars' oceans formed early, possibly aided by massive volcanic eruptions

Oceans formed before Tharsis and evolved together, shaping climate history of Mars

A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

New solar solutions for sustainable buildings and cities

23.03.2018 | Event News

Virtual reality conference comes to Reutlingen

19.03.2018 | Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

Latest News

For graphite pellets, just add elbow grease

23.03.2018 | Materials Sciences

Unique communication strategy discovered in stem cell pathway controlling plant growth

23.03.2018 | Agricultural and Forestry Science

Sharpening the X-ray view of the nanocosm

23.03.2018 | Physics and Astronomy

Science & Research
Overview of more VideoLinks >>>