Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UCSD Researchers ID Peptides That Bind to Alzheimer’s Plaques

09.09.2003


Two short protein segments, called peptides, have been identified by researchers at the University of California, San Diego (UCSD) School of Medicine, for their ability to recognize and bind to beta-amyloid-containing plaques that accumulate abnormally in the brains of Alzheimer’s disease patients, providing a possible “Trojan horse” mechanism to diagnose and treat the disorder.


Paul T. Martin, Ph.D.



“These peptide sequences are potential new tools for the delivery of medication to the amyloid plaques that are found in Alzheimer’s disease, or for new diagnostic tests that would allow early identification and treatment of the disease,” said the study’s senior author, Paul T. Martin, Ph.D., UCSD assistant professor of neurosciences.

In studies published in the September issue of the journal Neurobiology of Disease (published online Aug. 27, 2003), Martin and colleagues found that natural and synthetic versions of the peptides attach themselves to the abnormal plaque, while ignoring normal brain tissue.


Although past research has identified larger non-antibody and antibody proteins and small organic molecules that can bind to the amyloid plaques, the UCSD team said the newly discovered peptides may be a better choice for diagnosis and treatment. Smaller in size than previously identified proteins, the peptides may more easily cross the blood-brain barrier. In addition, some of the previously identified organic molecules could cause toxic side effects if given to people.

The scientists used a laboratory technique called phage peptide display to identify the two peptide sequences from a starting library of 50 million peptide sequences. These peptides were engineered to be exposed on the surface of bacteria by infecting the bacteria with bacteriophage (a bacterial virus). The peptide-expressing bacteria were then used to select for peptide sequences that bound amyloid plaques. An analysis of the bacteriophage showed that only the two peptides were able to seek out and bind to abnormal beta-amyloid.

“It is striking that we found only two peptide sequences, and that they were very similar in structure to one another,” Martin said. “This suggests that if other sequences do exist, they would most likely be variations on the structures we have already identified.”

He added that the UCSD team sees several potential applications for the peptides. First, they could be coupled to molecules designed to inhibit the toxicity of beta-amyloid plaques. The peptides might also be coupled to substances that stimulate the breakdown of plaques, or inhibit them from forming. A final application would be coupling the peptides to other markers that would highlight the abnormal plaque in imaging diagnostic tests. Currently, Alzheimer’s disease is diagnosed by cognitive tests involving patient interview, and a conclusive diagnosis requires postmortem analysis of the brain itself.

In addition to Martin, authors of the study included Christine Kang, staff research associate, and Vianney Jayasinha, an undergraduate student, in the UCSD Department of Neurosciences. The study was funded by the National Institutes of Health.

Contact:
Sue Pondrom
(619) 543-6163
spondrom@ucsd.edu

Sue Pondrom | UCSD
Further information:
http://health.ucsd.edu/news/2003/09_08_Martin.html
http://health.ucsd.edu/news/2002/04_15_Martin.html

More articles from Health and Medicine:

nachricht Antibiotic effective against drug-resistant bacteria in pediatric skin infections
17.02.2017 | University of California - San Diego

nachricht Tiny magnetic implant offers new drug delivery method
14.02.2017 | University of British Columbia

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Biocompatible 3-D tracking system has potential to improve robot-assisted surgery

17.02.2017 | Medical Engineering

Real-time MRI analysis powered by supercomputers

17.02.2017 | Medical Engineering

Antibiotic effective against drug-resistant bacteria in pediatric skin infections

17.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>