Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UCSD Researchers ID Peptides That Bind to Alzheimer’s Plaques

09.09.2003


Two short protein segments, called peptides, have been identified by researchers at the University of California, San Diego (UCSD) School of Medicine, for their ability to recognize and bind to beta-amyloid-containing plaques that accumulate abnormally in the brains of Alzheimer’s disease patients, providing a possible “Trojan horse” mechanism to diagnose and treat the disorder.


Paul T. Martin, Ph.D.



“These peptide sequences are potential new tools for the delivery of medication to the amyloid plaques that are found in Alzheimer’s disease, or for new diagnostic tests that would allow early identification and treatment of the disease,” said the study’s senior author, Paul T. Martin, Ph.D., UCSD assistant professor of neurosciences.

In studies published in the September issue of the journal Neurobiology of Disease (published online Aug. 27, 2003), Martin and colleagues found that natural and synthetic versions of the peptides attach themselves to the abnormal plaque, while ignoring normal brain tissue.


Although past research has identified larger non-antibody and antibody proteins and small organic molecules that can bind to the amyloid plaques, the UCSD team said the newly discovered peptides may be a better choice for diagnosis and treatment. Smaller in size than previously identified proteins, the peptides may more easily cross the blood-brain barrier. In addition, some of the previously identified organic molecules could cause toxic side effects if given to people.

The scientists used a laboratory technique called phage peptide display to identify the two peptide sequences from a starting library of 50 million peptide sequences. These peptides were engineered to be exposed on the surface of bacteria by infecting the bacteria with bacteriophage (a bacterial virus). The peptide-expressing bacteria were then used to select for peptide sequences that bound amyloid plaques. An analysis of the bacteriophage showed that only the two peptides were able to seek out and bind to abnormal beta-amyloid.

“It is striking that we found only two peptide sequences, and that they were very similar in structure to one another,” Martin said. “This suggests that if other sequences do exist, they would most likely be variations on the structures we have already identified.”

He added that the UCSD team sees several potential applications for the peptides. First, they could be coupled to molecules designed to inhibit the toxicity of beta-amyloid plaques. The peptides might also be coupled to substances that stimulate the breakdown of plaques, or inhibit them from forming. A final application would be coupling the peptides to other markers that would highlight the abnormal plaque in imaging diagnostic tests. Currently, Alzheimer’s disease is diagnosed by cognitive tests involving patient interview, and a conclusive diagnosis requires postmortem analysis of the brain itself.

In addition to Martin, authors of the study included Christine Kang, staff research associate, and Vianney Jayasinha, an undergraduate student, in the UCSD Department of Neurosciences. The study was funded by the National Institutes of Health.

Contact:
Sue Pondrom
(619) 543-6163
spondrom@ucsd.edu

Sue Pondrom | UCSD
Further information:
http://health.ucsd.edu/news/2003/09_08_Martin.html
http://health.ucsd.edu/news/2002/04_15_Martin.html

More articles from Health and Medicine:

nachricht Hot cars can hit deadly temperatures in as little as one hour
24.05.2018 | Arizona State University

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>