Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New "Gating" Device Improves Imaging of Heart and Lungs

08.09.2003


Magnetic resonance imaging (MRI) of the heart and lungs is a valuable diagnostic tool in the medical industry, but the detailed images it produces are often marred by artefacts (unwanted signals) created by the motion of cardiac and respiratory cycles.



A team of inventors at Oxford University has now developed a method of suppressing MRI artefacts to a negligible level. This has potential to allow more precise conclusions to be made from a small number of experimental trials, with obvious potential within the pharmaceutical industry, both to accelerate research work and to improve the robustness and quality of screening data upon which key project decisions can be made.

Cardiac and thoracic MRI of small animals, such as mice, requires high spatial resolution in order to resolve fine detail. However, MRI is extremely sensitive to motion from the cardiac and respiratory cycles, which cause severe image artefacts. To reduce these artefacts, synchronisation (gating) to these physiological cycles is required.


Successful gating itself, however, can be difficult to achieve:
· Severe interference from the MR gradient system can cause problems in obtaining clean physiological signals from which gating information is derived.
· Once gating information has been derived, a suitable intra-respiratory acquisition window has to be defined which allows ECGs within the window to be used for MRI signal acquisition.
· Physiological rates of small animals can vary due to changes in thermal or pharmacological response; these variations can invalidate the defined acquisition window, hence introducing motion artefacts.
· Unfortunately, using double-gating (i.e. cardiac and respiratory gating) creates another form of image artefact that has to be minimised.

To overcome these problems, the Oxford team has designed a cardiac and respiratory gating device that is immune from gradient system interference, is adaptive and flexible to changes in physiological rates, and minimises relaxation effects. The inventors have developed a prototype of the device that is capable of minimising image artefacts so that the resultant images are clearer, and therefore significantly better for identification purposes than those obtained using existing methods.

Isis Innovation, Oxford University’s technology transfer company, has filed a patent application on the gating device and is actively looking for companies interested in utilising it.

Jennifer Johnson | alfa
Further information:
http://www.isis-innovation.com/licensing/1275.html

More articles from Health and Medicine:

nachricht World first: Massive thrombosis removed during early pregnancy
20.07.2017 | Universitätsspital Bern

nachricht Therapy of preterm birth in sight?
19.07.2017 | Universitätsspital Bern

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA looks to solar eclipse to help understand Earth's energy system

21.07.2017 | Earth Sciences

Stanford researchers develop a new type of soft, growing robot

21.07.2017 | Power and Electrical Engineering

Vortex photons from electrons in circular motion

21.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>