Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New "Gating" Device Improves Imaging of Heart and Lungs

08.09.2003


Magnetic resonance imaging (MRI) of the heart and lungs is a valuable diagnostic tool in the medical industry, but the detailed images it produces are often marred by artefacts (unwanted signals) created by the motion of cardiac and respiratory cycles.



A team of inventors at Oxford University has now developed a method of suppressing MRI artefacts to a negligible level. This has potential to allow more precise conclusions to be made from a small number of experimental trials, with obvious potential within the pharmaceutical industry, both to accelerate research work and to improve the robustness and quality of screening data upon which key project decisions can be made.

Cardiac and thoracic MRI of small animals, such as mice, requires high spatial resolution in order to resolve fine detail. However, MRI is extremely sensitive to motion from the cardiac and respiratory cycles, which cause severe image artefacts. To reduce these artefacts, synchronisation (gating) to these physiological cycles is required.


Successful gating itself, however, can be difficult to achieve:
· Severe interference from the MR gradient system can cause problems in obtaining clean physiological signals from which gating information is derived.
· Once gating information has been derived, a suitable intra-respiratory acquisition window has to be defined which allows ECGs within the window to be used for MRI signal acquisition.
· Physiological rates of small animals can vary due to changes in thermal or pharmacological response; these variations can invalidate the defined acquisition window, hence introducing motion artefacts.
· Unfortunately, using double-gating (i.e. cardiac and respiratory gating) creates another form of image artefact that has to be minimised.

To overcome these problems, the Oxford team has designed a cardiac and respiratory gating device that is immune from gradient system interference, is adaptive and flexible to changes in physiological rates, and minimises relaxation effects. The inventors have developed a prototype of the device that is capable of minimising image artefacts so that the resultant images are clearer, and therefore significantly better for identification purposes than those obtained using existing methods.

Isis Innovation, Oxford University’s technology transfer company, has filed a patent application on the gating device and is actively looking for companies interested in utilising it.

Jennifer Johnson | alfa
Further information:
http://www.isis-innovation.com/licensing/1275.html

More articles from Health and Medicine:

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

Bodyguards in the gut have a chemical weapon

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>