Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists explain why Crohn disease is localized to specific regions of the gut

03.09.2003


Markus Neurath and fellow researchers at the University of Mainz, Germany, have characterized the interaction between intestinal bacteria and dendritic cells (DCs) that may provide an explanation for the clinical symptoms of Crohn disease that only occur in specific regions of the gut.



The authors used transgenic mice to investigate the expression of the p40 subunit of IL-12 and IL-23. The authors demonstrate that p40 is expressed by a newly identified subset of DCs at greater levels in the lower part of the small intestine when compared to the proximal part of the small intestine or the colon.

Neurath and colleagues demonstrate that p40 production is dependent on the intestinal bacteria as germ-free animals do not exhibit elevated p40 expression in the small intestine.


The data reveal important functional differences between the mucosal immune systems of the small and large bowel in healthy mice and suggest that the high numbers of bacteria in the terminal ileum activate p40 expression. The authors suggest that this pattern of p40 expression may explain the predisposition of the terminal ileum to develop chronic inflammation responses via IL-23 and may therefore provide a molecular reason for the preferential clinical manifestation of Crohn disease in this region of the gut.

In an accompanying commentary, Holm Uhlig and Fiona Powrie from the University of Oxford discuss how intestinal DCs sense bacteria in the gut. They also comment that the IL-12 p40 promoter transgenic mice produced by Neurath and coworkers "will be an excellent tool to study the interaction between particular bacteria and the host immune system and how this influences the localization of the immune response".


TITLE: Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

AUTHOR CONTACT:
Markus F. Neurath,
University of Mainz, Mainz, Germany
Phone: 49-6131-172374
Fax: 49-6131-175508
E-mail: neurath@1-med.klinik.uni-mainz.de


ACCOMPANYING COMMENTARY:
Dendritic cells and the intestinal bacterial flora: a role for localized mucosal immune responses

AUTHOR CONTACT:
Fiona Powrie
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
Phone: 44-1865-285494
Fax: 44-1865-275591
E-mail: fiona.powrie@pathology.ox.ac.uk

Brooke Grindlinger | EurekAlert!
Further information:
http://www.jci.org/
http://www.the-jci.org/press/19545.pdf
http://www.the-jci.org/press/17464.pdf

More articles from Health and Medicine:

nachricht Serious children’s infections also spreading in Switzerland
26.07.2017 | Universitätsspital Bern

nachricht New vaccine production could improve flu shot accuracy
25.07.2017 | Duke University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Carbon Nanotubes Turn Electrical Current into Light-emitting Quasi-particles

Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers

Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...

Im Focus: Flexible proximity sensor creates smart surfaces

Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.

At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA mission surfs through waves in space to understand space weather

25.07.2017 | Physics and Astronomy

Strength of tectonic plates may explain shape of the Tibetan Plateau, study finds

25.07.2017 | Earth Sciences

The dense vessel network regulates formation of thrombocytes in the bone marrow

25.07.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>