Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Mouse, stripped of a key gene, resists diabetes


An engineered mouse, already known to be immune to the weight gain ramifications of a high-calorie, high-fat diet, now seems able to resist the onset of diabetes.

Professor of biochemistry and nutritional sciences James Ntambi holds two mice in his research lab and points to the mouse that is missing a SCD-1 gene and is significantly thinner than the normal mouse at right. Ntambi recently found that subracting a single gene, SCD-1, from the genome of a mouse creates an animal that can eat a rich, high-fat diet without gaining weight or risking the complications of diabetes.
Photo by: Jeff Miller
Date: August 2002

The mouse, stripped of a gene known as SCD-1, is apparently impervious to the negative effects of the type of diet that, for many people, has significant health and social consequences.

"We think this animal model may be protected against diabetes," says James Ntambi, a University of Wisconsin-Madison professor of biochemistry and Steenbock professor of nutrition, and the senior author of a report describing the remarkable mouse in this week’s (Sept. 1) online editions of the Proceedings of the National Academy of Sciences (PNAS).

The new finding is important because it provides critical genetic and biochemical clues to diet, obesity and the onset of a disease that affects as much as 6 percent of the U.S. population.

Type II diabetes, which accounts for about 90 percent of the incidence of diabetes in the United States, is a chronic disease caused by a problem in the way the body makes or uses insulin. Insulin is a hormone secreted by the pancreas that, under healthy circumstances, plays an essential role in moving glucose from blood to cells where the sugar’s energy is expended.

In many instances, obesity and diabetes go hand in hand. Between 75 and 80 percent of people with type II diabetes are obese, although the disease can also develop in lean people, especially the elderly.

The discovery of a gene that seems to exercise significant influence over both weight gain and glucose regulation promises a potentially significant window into both conditions and their relationship. The gene makes an enzyme called SCD. It affects the production of fatty acids, and because humans have SCD-1 equivalents, the new finding helps explain why some people, who may lack the gene, remain lean and diabetes free, despite a rich, fatty diet.

"We are beginning to suspect that obese individuals have increased expression of this enzyme," says Ntambi. "If you reduce expression of this enzyme, you reduce fat expression in muscle."

This new insight into the gene and its influence could herald the development of new drugs to prevent both diabetes and obesity as it may help scientists zero in on the underlying problems that lead to both conditions.

In the engineered mice, the Wisconsin team observed that muscle cells were more sensitive to insulin, enabling the cells to absorb glucose and avoid hyperglycemia. Elevated levels of glucose in the blood prompt the pancreas to produce more insulin, which tends to make cells even more resistant to the critical hormone.

"In this animal, there is increased insulin signaling or sensitivity," Ntambi explains. "When insulin binds to the cell’s insulin receptor, it triggers a cascade of events " that enables the animal to successfully regulate levels of blood sugar.

"There are lots of steps involved in the process, and in the case of type II diabetes things go wrong in some of those events," Ntambi says. "What we found in these animals is that the insulin signaling steps in muscle are all enhanced, despite low levels of insulin in plasma. We don’t see a defect yet."

The work by the Wisconsin team was funded primarily by the National Institutes of Health and in part by a grant from Xenon Genetics, Inc.

In addition to Ntambi, co-authors of the PNAS report include Shaikh Mizanoor Rahman, Agnieszka Dobrzyn, Pawel Dobrzyn, Seong-Ho Lee and Makoto Miyazaki.

- Terry Devitt (608) 262-8282,

James Ntambi | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>