Recoverying from third and fourth degree burns, the most damaging types, is a slow and painful process that inevitably leaves excessive scar tissue. Russian researchers have developed a pharmacological enzyme preparation to accelerate the debridement process and wound healing, which reduces the preparation time for grafting and diminishes scarring.
Their product, called ENZYCOL, is a mixture of collagenases from the Kamchatka crab that rapidly dissolves the dense collagen matrix of necrotic skin forming after a burn. By removing this non-living tissue, ENZYCOL promotes the healing of the surrounding healthy tissue, a vital process for preventing the onset of infection. The debridement period for burns pre-treated with the crab collagenase mixture is 2 days shorter than with traditional enzyme therapies such as trypsin.
The research team consisted of scientists from the Russian Cardiology Research Center in Moscow and the Research Center of Toxicology and Hygienic Regulation of Biopreparations in Serpukhov (Moscow Region). Seventy-one scientists and technical staff, of which forty represented former biological and chemical weapons experts, participated in two ISTC projects to develop this technology. They began their work in 1999 to develop the powder preparation and confirm its safety and effectiveness in vitro. In the follow-up project, which began in 2002 and is currently going on, the scientists modified the method for preparing ENZYCOL to make it suitable for pilot scale production. They also performed pre-clinical trials on laboratory animals, which proved that the enzyme cocktail is non-toxic, non-mutagenic, and non-irritating on skin.
Alexander Ivanchenko | alfa
'Icebreaker' protein opens genome for t cell development, Penn researchers find
21.02.2018 | University of Pennsylvania School of Medicine
Similarities found in cancer initiation in kidney, liver, stomach, pancreas
21.02.2018 | Washington University School of Medicine
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
21.02.2018 | Life Sciences
21.02.2018 | Life Sciences
21.02.2018 | Materials Sciences