ESC Congress 2003
Adult heart cells have limited regenerative capacity and therefore any significant cell loss, such as occurs during a heart attack, is mostly irreversible and may lead to the development of progressive heart failure. Congestive heart failure is one of the leading causes of morbidity and mortality in the western world, placing a significant economic burden on the health care systems. Despite advances in the medical, interventional, and surgical therapeutic measures, the prognosis for these patients remains unacceptably poor. With a chronic lack of donors limiting the number of patients who can benefit from heart transplantations, development of new therapeutic paradigms for heart failure has become imperative
A potential novel therapeutic approach for this situation may be to replace the dysfunctional or scarred tissue with new myogenic cells. However, this cell replacement strategy has been hampered by the lack of cell sources for human heart cells and by the lack of direct evidence for functional integration of donor and host tissues. We describe the establishment of a novel source of cardiomyocytes for cell therapy, the human embryonic stem cell differentiating system. Our results demonstrate that these unique cells can differentiate in the dish to generate spontaneously contracting tissue with the structural and functional properties of cardiac cells. We also demonstrate that the generated cardiac tissue can integrate in vitro with preexisting cardiac cultures as to form a single functional unit.
Camilla Dormer | alfa
Millions through license revenues
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New High-Performance Center Translational Medical Engineering
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More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
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