Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Stem cells therapy is a safe tool for mending broken hearts

02.09.2003


ESC Congress 2003: Stem cells – A tool for mending broken hearts?



We have shown that stem cell injections by catheters into diseased hearts are feasible and safe, even for very sick patients. Moreover, the results suggested strongly a potential ability of these cells to regenerate the arteries of the heart (called coronary arteries), and this regeneration improved the mechanical function of the heart, improving the heart failure condition of these patients. Since heart failure is a more aggressive killer than most cancers, and the fact that cardiovascular diseases are the leading cause of mortality around the world, this could be a beginning of a “new era” in cardiovascular therapy.

Our study was carried out at Pró-Cardíaco Hospital (granted by the Filantropic Foundation of Teaching and Research of Pró-Cardíaco Hospital - PROCEP), in Rio de Janeiro, with a partnership with the Federal University of Rio de Janeiro and Texas Heart Institute. The experimental models were developed by the Federal University (granted by the Ministry of Science and Technology) and the injection system used to introduce the cells into the heart was developed by Johnson&Johnson, and tested in Houston.


We enrolled 21 patients in this study. All patients had an end stage coronary artery disease, which means no possibility of proceeding to a bypass surgery or to an angioplasty (treatment of the coronary arteries using a catheter). This advanced disease in coronary arteries is responsible for damages in the heart’s muscle, characterizing a heart failure condition.

The first 14 patients were submitted to an autologous transplantation of cells from bone marrow into the cardiac muscle, aiming to create new small arteries in the heart, which would make possible a more effective supply of blood to the damaged muscle. The other 7 patients were enrolled as a control group, and were followed up during the same one year period.

Considering the safety data, there were no major adverse effects observed in this group of patients. There was one death in the control group at the second week after the enrollment. In the treated group we observed two deaths, the first at the fourteenth week and the last one up to the ninth month of follow up. Both deaths could not be considered as related to the cell procedure, as analyzed by the Steering Committee of the study. Actually, the expected mortality for these patients is around 53% in 6 months.

Considering the efficacy data, the treated patients had a significant 71% reduction of the muscle areas with impaired blood supply, while we observed an increase of this parameter in the control group. The better blood supply allowed a 40% improvement of the heart’s mechanical function only observed on treated patients.

These improvements in blood supply and mechanical function reflected on patients’ quality of life as evaluated by a specific tool for this purpose (SF-36 – a general health evaluation questionnaire). This questionnaire evaluates 8 aspects of general health and its impact on patients’ quality of life. When comparing the patients’ data at baseline to the average data of the general American population, we observed a very low score in all 8 aspects. At 8 weeks of follow up we observed an improvement in 7 of the 8 aspects, which are comparable to the general American population average.

A subgroup of 5 patients was listed for heart transplant and at the end of six months of follow up, 4 of them did not match the clinical conditions to be eligible for the procedure. These data have social relevance once there isn’t a single heart transplant program around the world which is able to treat all patients who need it.

Since this is a phase I study with a small number of patients, our findings need to be confirmed in new studies oriented to the efficacy of this procedure, as randomized, double-blind, placebo controlled trials, with a larger number of patients.

Hans Fernando Rocha Dohmann MD, MBA
Pró-Cardíaco Hospital, Rio de Janeiro
Brazil

Important: This press release accompanies both a presentation and an ESC press conference given at the ESC Congress 2003. Written by the investigator himself/herself, this press release does not necessarily reflect the opinion of the European Society of Cardiology

Camilla Dormer | alfa
Further information:
http://www.escardio.org

More articles from Health and Medicine:

nachricht Investigators may unlock mystery of how staph cells dodge the body's immune system
22.09.2017 | Cedars-Sinai Medical Center

nachricht Monitoring the heart's mitochondria to predict cardiac arrest?
21.09.2017 | Boston Children's Hospital

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Rainbow colors reveal cell history: Uncovering β-cell heterogeneity

22.09.2017 | Life Sciences

Penn first in world to treat patient with new radiation technology

22.09.2017 | Medical Engineering

Calculating quietness

22.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>